Evidence map›Paper›PMID 36825154›Full record

ArticleFrontiers in pharmacology2023

Formulation development of lipid polymer hybrid nanoparticles of doxorubicin and its

Muhammad Shafique, Maqsood Ur Rehman, Zul Kamal, Rami M Alzhrani, Sameer Alshehri, Ali H Alamri, Mohammed Ali Bakkari, Fahad Y Sabei, Awaji Y Safhi, Ahmed M Mohammed and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

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  8. Engineering Nanoparticles and Bioscaffolds for Targeted microRNA Delivery in Cardiovascular Regeneration-A Comprehensive Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Muhammad ShafiqueDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Maqsood Ur RehmanDepartment of Pharmaceutics, School of Pharmacy, University College London, London, United Kingdom.
Zul KamalDepartment of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, (Dir Upper), Pakistan.
Rami M AlzhraniDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Sameer AlshehriDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Ali H AlamriDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Mohammed Ali BakkariDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Fahad Y SabeiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Awaji Y SafhiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Ahmed M MohammedDepartment of pharmaceutics and pharmaceutical technology Faculty of Pharmacy Al-azhar University, Assiut, Egypt.
Mohamed A El HamdDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Saud AlmawashDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Jazan University · SAShaqra University · SATaif University · SAAl-Azhar University · EGKing Khalid University · SAShaheed Benazir Bhutto University · PKSouth Valley University · EGUniversity of Malakand · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to assess the parameters of doxorubicin (DOX) loaded lipid polymer hybrid nanoparticles (LPHNs) formulation development, and then the bioavailability of DOX were determined in the rabbit model, in order to evaluate the intrinsic outcome of dosage form improvement after the oral administration. LPHNs were prepared by combine approach, using both magnetic stirring and probe sonication followed by its characterization in terms of size-distribution (Zeta Size), entrapment efficiency (EE), loading capacity, and the kinetics of DOX. LPHNPs were further characterized by using scanning electron microscopy (SEM), powder X-Ray diffractometry (P-XRD), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC),

Indexed as

bioavailabilitydoxorubicinin vitroin vivolipid polymer hybrid nanoparticles

Identifiers

PMID36825154
PMCPMC9941671
OpenAlexW4319440072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.