SynthesisInfluenza and other respiratory viruses2022
Transmission of SARS-CoV-2 in standardised first few X cases and household transmission investigations: A systematic review and meta-analysis.
Abstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in Influenza and other respiratory viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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14citing papers in PubMed, 4 pooled it
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Asymptomatic Proportion of SARS-CoV-2 Omicron Variant Infections in Households: A Systematic Review.Influenza and other respiratory viruses · 2024Pooled it
- Household transmission investigation: Design, reporting and critical appraisal.Influenza and other respiratory viruses · 2023Pooled it
- A framework for seroepidemiologic investigations in future pandemics: insights from an evaluation of WHO's Unity Studies initiative.Health research policy and systems · 2023Pooled it
- Transmission of SARS-CoV-2 in standardised first few X cases and household transmission investigations: A systematic review and meta-analysis.Influenza and other respiratory viruses · 2022Pooled it
- Evaluating COVID-19 Transmission in a Series of Cases and Contacts in Three Municipalities of Colombia: Insights From the WHO First Few X Protocol, August 2020-January 2021.Influenza and other respiratory viruses · 2026Article
- Article
- Article
- Estimating Asymptomatic and Symptomatic Transmission of the COVID-19 First Few Cases in Selenge Province, Mongolia.Influenza and other respiratory viruses · 2024Article
- WHO's Investigations and Studies, Unity Studies: A global initiative creating equitable opportunities for enhanced surveillance, operational research, capacity building, and global knowledge sharing.Influenza and other respiratory viruses · 2024Article
- Leveraging new methodologies for public health crisis management.Frontiers in public health · 2024Article
- Transmissibility and severity of COVID-19 in a humanitarian setting: First few X investigation of cases and contacts in Juba, South Sudan, 2020.Influenza and other respiratory viruses · 2023Article
- The Role of Children in Household Transmission of SARS-CoV-2 Across Four Waves of the Pandemic.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Impact of Vaccination With the SCB-2019 Coronavirus Disease 2019 Vaccine on Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Household Contact Study in the Philippines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Learnings from the Australian first few X household transmission project for COVID-19.The Lancet regional health. Western Pacific · 2022Article
Corrections and comments
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Authors and funding
73 authors.
Hannah C LewisWorld Health Organization Geneva Switzerland.ORCID 0000-0002-1925-3943
Adrian J MarcatoDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0001-5951-6886
Niamh MeagherDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0001-5324-8307
Marta ValencianoWorld Health Organization Geneva Switzerland.ORCID 0000-0002-2056-1062
Juan-Pablo Villanueva-CabezasDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0002-8575-9141
Violeta SpirkoskaDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0002-0600-4569
James E FieldingDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0003-2995-9576
Amalia KarahaliosCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne Melbourne Australia.ORCID 0000-0002-7497-1681
Lorenzo SubissiWorld Health Organization Geneva Switzerland.ORCID 0000-0001-5147-575X
Anthony NardoneWorld Health Organization Geneva Switzerland.ORCID 0000-0003-1138-0937
Brianna ChengWorld Health Organization Geneva Switzerland.ORCID 0000-0003-2004-2251
Soatiana RajatonirinaWorld Health Organization, Regional Office for Africa Brazzaville Republic of Congo.ORCID 0000-0002-5869-5090
Joseph OkeibunorWorld Health Organization, Regional Office for Africa Brazzaville Republic of Congo.ORCID 0000-0002-6696-8503
Eman A AlyWorld Health Organization, Regional Office for the Eastern Mediterranean Cairo Egypt.ORCID 0000-0002-4603-3911
Amal BarakatWorld Health Organization, Regional Office for the Eastern Mediterranean Cairo Egypt.ORCID 0000-0002-9446-3035
Pernille JorgensenWorld Health Organization Regional Office for Europe Copenhagen Denmark.ORCID 0000-0001-5967-0998
Tasnim AzimWorld Health Organization, Regional Office for South-East Asia New Delhi India.ORCID 0000-0003-4127-5871
Pushpa R WijesingheWorld Health Organization, Regional Office for South-East Asia New Delhi India.ORCID 0000-0002-7875-0165
Linh-Vi LeWorld Health Organization, Regional Office for the Western Pacific Manila Philippines.ORCID 0000-0002-5816-7589
Angel RodriguezWorld Health Organization, Regional Office for the Americas (Pan American Health Organization) Washington DC USA.ORCID 0000-0002-0061-7567
Andrea VicariWorld Health Organization, Regional Office for the Americas (Pan American Health Organization) Washington DC USA.ORCID 0000-0001-5528-2517
Maria D Van KerkhoveWorld Health Organization Geneva Switzerland.ORCID 0000-0002-6135-0018
Jodie McVernonDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0001-9774-1961
Richard PebodyWorld Health Organization Regional Office for Europe Copenhagen Denmark.ORCID 0000-0002-9069-2885
David J PriceDepartment of Infectious Diseases The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne Australia.ORCID 0000-0003-0076-3123
Isabel BergeriWorld Health Organization Geneva Switzerland.ORCID 0000-0002-1204-1753
Unity Studies Collaborator Group
Lubna Al AriqiWorld Health Organization, Regional Office for the Eastern Mediterranean Cairo Egypt.
Mikias A AlemuEthiopian Public Health Institute Addis Ababa Ethiopia.
Yasir AlviDepartment of Community Medicine Hamdard Institute of Medical Sciences and Research New Delhi India.
Elizabeth A BukusiKenya Medical Research Institute Nairobi Kenya.
Pui Shan ChungWorld Health Organization, Regional Office for the Western Pacific Manila Philippines.
Davaalkham DambadarjaaSchool of Public Health Mongolian National University of Medical Sciences Ulaanbaatar Mongolia.
Ayan K DasDepartment of Microbiology Hamdard Institute of Medical Science and Research New Delhi India.
Timothée DubDepartment of Health Security Finnish Institute for Health and Welfare Helsinki Finland.
Diba DulachaWHO Country Office Juba South Sudan.
Faiqa EbrahimWorld Health Organization Country Office Addis Ababa Ethiopia.
Maritza A González-DuarteNational Institute of Health Bogotá Colombia.
Dinuka GurugeColombo Municipality Council Colombo Sri Lanka.
Jean-Michel HeraudInstitut Pasteur de Madagascar Antananarivo Madagascar.
Damaris C Heredia-MeloNational Institute of Health Bogotá Colombia.
Amy Herman-RoloffU.S. Centers for Disease Control and Prevention Nairobi Kenya.
Belinda L HerringWorld Health Organization, Regional Office for Africa Brazzaville Republic of Congo.
Francis Y InbanathanWorld Health Organization, Regional Office for South-East Asia New Delhi India.
Farzana IslamHamdard Institute of Medical Sciences and Research (HIMSR) New Delhi India.
Kamal Chandima JeewandaraAllergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura Nugegoda Sri Lanka.
Shashi KantCentre for Community Medicine All India Institute of Medical Sciences New Delhi India.
Wasiq KhanWorld Health Organization, Regional Office for the Eastern Mediterranean Cairo Egypt.
Richard LakoMinistry of Health Juba South Sudan.
Juliana LeiteWorld Health Organization, Regional Office for the Americas (Pan American Health Organization) Washington DC USA.
Gathsaurie Neelika MalavigeFaculty of Medical Sciences University of Sri Jayawardenapura Nugegoda Sri Lanka.
Undram MandakhMongolian National University of Medical Sciences Ulaanbaatar Mongolia.
Warisha MariamDepartment of Community Medicine Maulana Azad Medical College New Delhi India.
Tsogt MendNational Center for Communicable Diseases Ulaanbaatar Mongolia.
Valerie A MizeWHO Country Office Juba South Sudan.
Sanjin MusaInstitute for Public Health of the Federation of Bosnia and Herzegovina Sarajevo Bosnia and Herzegovina.
Hanna NohynekDepartment of Health Security Finnish Institute for Health and Welfare Helsinki Finland.
Olushayo O OluWHO Country Office Juba South Sudan.
May B Osorio-MerchánNational Institute of Health Bogotá Colombia.
Dmitriy PereyaslovWorld Health Organization Geneva Switzerland.
Rindra Vatosoa RandremananaInstitut Pasteur de Madagascar Antananarivo Madagascar.
Mamy Jean de Dieu RandriaCentre Hospitalier Universitaire Joseph Raseta Befelatanana Antananarivo Madagascar.
James RansomCenters for Disease Control and Prevention Juba South Sudan.
Sonal SaxenaDepartment of Microbiology Maulana Azad Medical College New Delhi India.
Pragya SharmaDepartment of Community Medicine Maulana Azad Medical College New Delhi India.
Aswathy SreedeviDepartment of Community Medicine Amrita Institute of Medical Sciences Kochi Kerala India.
Mini SatheeshKerala University of Health Sciences Kerala India.
K J SubhashiniCentre for Community Medicine All India Institute of Medical Sciences New Delhi India.
Beth A Tippet-BarrU.S. Centers for Disease Control and Prevention Nairobi Kenya.
Anuja UshaRegional Prevention of Epidemic and Infectious Disease Cell Government of Kerala Kerala India.
Joseph F WamalaWHO Country Office Juba South Sudan.
Shambel H WatareEthiopian Public Health Institute Addis Ababa Ethiopia.
Kapil YadavCentre for Community Medicine All India Institute of Medical Sciences New Delhi India.
Funding
World Health Organization 001
Abstract
We aimed to estimate the household secondary infection attack rate (hSAR) of SARS-CoV-2 in investigations aligned with the WHO Unity Studies Household Transmission Investigations (HHTI) protocol. We conducted a systematic review and meta-analysis according to PRISMA 2020 guidelines. We searched Medline, Embase, Web of Science, Scopus and medRxiv/bioRxiv for "Unity-aligned" First Few X cases (FFX) and HHTIs published 1 December 2019 to 26 July 2021. Standardised early results were shared by WHO Unity Studies collaborators (to 1 October 2021). We used a bespoke tool to assess investigation methodological quality. Values for hSAR and 95% confidence intervals (CIs) were extracted or calculated from crude data. Heterogeneity was assessed by visually inspecting overlap of CIs on forest plots and quantified in meta-analyses. Of 9988 records retrieved, 80 articles (64 from databases; 16 provided by Unity Studies collaborators) were retained in the systematic review; 62 were included in the primary meta-analysis. hSAR point estimates ranged from 2% to 90% (95% prediction interval: 3%-71%;
Indexed as
COVID-19Influenza, HumanFamily CharacteristicsHumansPandemicsSARS-CoV-2epidemiologic studiesfamily characteristics (household)pandemicSARS‐CoV‐2systematic review and meta‐analysistransmission
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