Evidence map›Paper›PMID 36825016›Full record

ArticleFrontiers in immunology2023

Zika virus induced microcephaly and aberrant hematopoietic cell differentiation modeled in novel neonatal humanized mice.

Kimberly Schmitt, James Z Curlin, Leila Remling-Mulder, Tawfik Aboellail, Ramesh Akkina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Virus as Teratogenic Agents.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimberly SchmittDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States.
James Z CurlinDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States.
Leila Remling-MulderDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States.
Tawfik AboellailDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States.
Ramesh AkkinaDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States.
Colorado State University · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Modeling the molecular evolution of SIV to HIV using humanized miceR01AI123234 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2016 to 2020
$2.4M
NCATS NIH HHS UL1 TR002535NIAID NIH HHS R01 AI123234
6 · The paper itself

Abstract

Introduction: Immunocompetent and immunocompromised murine models have been instrumental in answering important questions regarding ZIKV pathogenesis and vertical transmission. However, mimicking human congenital zika syndrome (CZS) characteristics in these murine models has been less than optimal and does not address the potential viral effects on the human immune system. Methods: Here, we utilized neonatal humanized Rag2 Results: Within 13 days, mice displayed outward clinical symptoms that encompassed stunted growth, hunched posture, ruffled fur, and ocular defects. Striking gross pathologies in the brain and visceral organs were noted. Our results also confirmed that ZIKV actively infected human CD34 Discussion: Overall, this model recapitulated ZIKV microcephaly and CZS together with viral adverse effects on the human immune cell ontogeny thus providing a unique

Indexed as

MicrocephalyNervous System MalformationsZika Virus InfectionAnimalsCell DifferentiationHumansMiceZika VirusA dual-purpose hu-mouse model for Zikahumanized mouse model for Zika microcephalyModeling Zika pathologies in newbornsNeonatal hu-mouse model for ZikaNeuronal impairment by Zika in childhoodZika viral effects on human CD34+ HSCZika virus and aberrant B cell developmentZika virus and hematopoiesis

Identifiers

PMID36825016
PMCPMC9941325
OpenAlexW4319442938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.