Evidence map›Paper›PMID 36824979›Full record

ArticlebioRxiv : the preprint server for biology2023

Spatial heterogeneity in biofilm metabolism elicited by local control of phenazine methylation.

Christopher R Evans, Marina K Smiley, Sean Asahara Thio, Mian Wei, Alexa Price-Whelan, Wei Min, Lars E P Dietrich

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christopher R EvansDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Marina K SmileyDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Sean Asahara ThioDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Mian WeiDepartment of Chemistry, Columbia University, New York, NY 10025.
Alexa Price-WhelanDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Wei MinDepartment of Chemistry, Columbia University, New York, NY 10025.
Lars E P DietrichDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Columbia University · US

Funding

Integration of redox-balancing mechanisms in Pseudomonas aeruginosa biofilmsR01AI103369 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DIETRICH, LARS · 2013 to 2022
$4.1M
High-resolution volumetric imaging of metabolic activity in tissues and its application to tumor metabolismR01EB029523 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MIN, WEI · 2020 to 2023
$1.6M
NIAID NIH HHS R01 AI103369NIBIB NIH HHS R01 EB029523
6 · The paper itself

Abstract

Within biofilms, gradients of electron acceptors such as oxygen stimulate the formation of physiological subpopulations. This heterogeneity can enable cross-feeding and promote drug resilience, features of the multicellular lifestyle that make biofilm-based infections difficult to treat. The pathogenic bacterium

Indexed as

biofilm physiologyBiological Sciences (major)carbon catabolite repressionmetabolic heterogeneityMicrobiology (minor)PhzMpyocyaninself-resistance

Identifiers

PMID36824979
PMCPMC9949047
OpenAlexW4321018636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.