Evidence map›Paper›PMID 36824944›Full record

ArticleResearch square2023

Detection, Visualization and Quantification of Protein Complexes in Human Alzheimer's Disease Brains using Proximity Ligation Assay.

Wilber Romero-Fernandez, Cristian Carvajal-Tapia, Alex Prusky, Ketaki Katdare, Emmeline Wang, Alena Shostak, Lissa Ventura-Antunes, Hannah Harmsen, Ethan Lippmann, Dasiel Borroto-Escuela and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Wilber Romero-FernandezVanderbilt University Medical Center.ORCID 0000-0001-9868-8074
Cristian Carvajal-TapiaVanderbilt University Medical Center.
Alex PruskyVanderbilt University Medical Center.
Ketaki KatdareVanderbilt University.
Emmeline WangVanderbilt University Medical Center.
Alena ShostakVanderbilt University Medical Center.
Lissa Ventura-AntunesVanderbilt University Medical Center.
Hannah HarmsenVanderbilt University Medical Center.
Ethan LippmannVanderbilt University.
Dasiel Borroto-EscuelaKarolinska Institute.
Jason MacGurnVanderbilt University.
Kjell FuxeKarolinska Institute.
Matthew SchragVanderbilt University Medical Center.
Vanderbilt University Medical Center · USVanderbilt University · USKarolinska Institutet · SE

Funding

Elucidating Molecular Drivers of Aging and Alzheimer's Disease via Multimodal Imaging Mass SpectrometryR01AG078803 · NIA · VANDERBILT UNIVERSITY · PI Rena A. S. Robinson, Matthew Schrag · 2022 to 2026
$3.5M
Defective lysosomal membrane fission mediates axonal lysosome accumulation in dystrophic neurites in Alzheimer's disease.K76AG060001 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SCHRAG, MATTHEW · 2019 to 2023
$1.2M
NIA NIH HHS K76 AG060001NIA NIH HHS R01 AG078803
6 · The paper itself

Abstract

Examination of healthy and diseased human brain is essential to translational neuroscience. Protein-protein interactions play a pivotal role in physiological and pathological processes, but their detection is difficult, especially in aged and fixed human brain tissue. We used the proximity ligation assay (PLA) to broaden the range of molecular interactions assessable

Identifiers

PMID36824944
PMCPMC9949263
OpenAlexW4321016276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.