ArticleResearch square2023
Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
Open access · greenAbstract readPreprint
In one paragraph
Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 7 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
163 authors at 20 institutions in 14 countries.
Azmeraw AmareUniversity of Adelaide, AUSTRALIA.ORCID 0000-0002-7940-0335
Anbupalam ThalamuthuUniversity of New South Wales.
Klaus Oliver SchubertUniversity of Adelaide.ORCID 0000-0003-1690-0209
Janice FullertonNeuroscience Research Australia.ORCID 0000-0003-4014-4490
Muktar AhmedUniversity Hospital LMU.
Simon HartmannUniversity Hospital LMU.
Sergi PapiolUniversity Hospital LMU.ORCID 0000-0001-9366-8728
Urs HeilbronnerUniversity Hospital, LMU Munich.ORCID 0000-0001-7135-762X
Franziska DegenhardtUniversity of Bonn.
Fasil Tekola-AyeleNational Institute of Mental Health.
Liping HouNational Institute of Mental Health.
Yi-Hsiang HsuUniversity of California San Diego.
Tatyana ShekhtmanUniversity of California San Diego.
Mazda AdliCharité - Universitätsmedizin Berlin, Campus Charité Mitte.
Nirmala AkulaDokkyo Medical University School of Medicine.
Kazufumi AkiyamaDokkyo Medical University School of Medicine.
Raffaella ArdauHospital University Agency of Cagliari.
Bárbara AriasFacultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM.
Jean-Michel AubryGeneva University Hospitals.
Lena BacklundUniversity of California San Diego.
Abesh Kumar BhattacharjeeUniversity of California San Diego.
Frank BellivierPôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal.
Antoni BenabarreHospital Clinic of Barcelona.
Susanne BengesserMedical University of Graz.
Joanna BiernackaMayo Clinic.ORCID 0000-0001-9350-4440
Armin BirnerMedical University of Graz.
Cynthia Marie-ClaireINSERM UMR-S 1144.ORCID 0000-0002-2282-134X
Pablo CervantesMcGill University Health Centre.
Hsi-Chung ChenNational Taiwan University Hospital.ORCID 0000-0003-3191-0093
Caterina ChillottiResearch Center Juelich.
Sven CichonResearch Center Juelich.ORCID 0000-0002-9475-086X
Cristiana CruceanuMax Plank Institute for Psychiatry.ORCID 0000-0002-7799-5531
Piotr CzerskiPoznan University of Medical Sciences.ORCID 0000-0003-0745-5916
Nina DalknerMedical University of Graz.
Maria Del ZompoUniversity of Cagliari.ORCID 0000-0001-9491-5938
J Raymond DePauloJohns Hopkins University.
Bruno EtainInserm U955, Psychiatry Genetics.ORCID 0000-0002-5377-1488
Stéphane JamainUniv Paris Est Creteil, INSERM, IMRB.ORCID 0000-0002-4321-4100
Peter FalkaiUniversity Hospital LMU.
Andreas J ForstnerUniversity of Bonn, School of Medicine & University Hospital Bonn.ORCID 0000-0002-1876-6368
Louise FrisénKarolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital.
Mark FryeMayo Clinic.ORCID 0000-0001-6997-4215
Sébastien GardHôpital Charles Perrens.
Julie GarnhamORCID 0000-0002-7987-4995
Fernando GoesORCID 0000-0001-6262-8264
Maria Grigoroiu-SerbanescuAlexandru Obregia Clinical Psychiatric Hospital.ORCID 0000-0002-1304-6687
Andreas FallgatterUniversity of Tuebingen.
Sophia StegmaierUniversity of Tuebingen.
Thomas EthoferUniversity Hospital Tübingen.
Silvia BiereUniversity Hospital Tübingen.
Kristiyana PetrovaUniversity Hospital Tübingen.
Ceylan SchusterUniversity Hospital Tübingen.
Kristina AdorjanLudwig Maximilian University of Munich.
Monika BuddeLudwig Maximilian University of Munich.
Maria HeilbronnerUniversity Hospital Tübingen.
Janos KalmanLudwig Maximillians Universitat Muenchen.ORCID 0000-0003-0930-4214
Mojtaba Oraki KohshourLudwig Maximillians Universitat Muenchen.
Daniela Reich-ErkelenzKlinikum der Universität München.
Sabrina SchauppUniversity Hospital Tübingen.
Eva SchulteUniversity Hospital, LMU Munich.ORCID 0000-0003-3105-5672
Fanny SennerKlinikum der Universität München.
Thomas VoglUniversity Hospital Tübingen.
Ion-George AnghelescuRuhr University Bochum.
Volker AroltRuhr University Bochum.
Udo DannlowskiRuhr University Bochum.
Detlef E DietrichRuhr University Bochum.
Christian FiggeRuhr University Bochum.
Markus JägerRuhr University Bochum.
Fabian LangRuhr University Bochum.
Georg JuckelRuhr University Bochum.
Carsten SpitzerLudwig-Maximilians-University (LMU) Munich.
Jens ReimerLudwig-Maximilians-University (LMU) Munich.
Max SchmaußLudwig-Maximilians-University (LMU) Munich.
Andrea SchmittLudwig-Maximilians-University (LMU) Munich.
Carsten KonradUniversitätsmedizin Göttingen.
Martin von HagenUniversitätsmedizin Göttingen.
Jens WiltfangUniversitätsmedizin Göttingen.ORCID 0000-0003-1492-5330
Jörg ZimmermannTechnical University of Munich, Klinikum rechts der Isar.
Till AndlauerTechnical University of Munich, Klinikum rechts der Isar.ORCID 0000-0002-2917-5889
Andre FischerUniversity of Goettingen, Germany.
Felix BermpohlBerlin School of Mind & Brain.
Vivien KraftGoethe University Frankfurt/M.
Silke MaturaGoethe University Frankfurt/M.
Anna GryaznovaUniversity Medical Center Hamburg-Eppendorf.
Irina FalkenbergUniversity Medical Center Hamburg-Eppendorf.
Cüneyt YildizUniversity Medical Center Hamburg-Eppendorf.
Tilo KircherUniversity Medical Center Hamburg-Eppendorf.
Julia SchmidtUniversity Medical Center Hamburg-Eppendorf.
Marius KochUniversity Medical Center Hamburg-Eppendorf.
Katrin GadeUniversity Medical Center Hamburg-Eppendorf.
Sarah TrostUniversity Medical Center Hamburg-Eppendorf.
Ida HaußleiterUniversity Medical Center Hamburg-Eppendorf.
Martin LambertUniversity Medical Center Hamburg-Eppendorf.
Anja C RohenkohlUniversity Medical Center Hamburg-Eppendorf.
Vivien KraftUniversity Medical Center Hamburg-Eppendorf.ORCID 0000-0002-5815-1026
Paul GrofMcGill University.
Ryota HashimotoInstitute of Human Genetics.
Joanna HauserInstitute of Human Genetics.ORCID 0000-0002-6621-3493
Stefan HermsInstitute of Human Genetics.
Per HoffmannInstitute of Human Genetics.
Esther JiménezCollege of Public Health, National Taiwan University, Taipei, Taiwan.
Jean-Pierre KahnCollege of Public Health, National Taiwan University, Taipei, Taiwan.
Layla KassemCollege of Public Health, National Taiwan University, Taipei, Taiwan.
Po-Hsiu KuoCollege of Public Health, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-0365-3587
Tadafumi KatoUniversity Hospital of Würzburg.
John KelsoeUniversity Hospital of Würzburg.
Sarah Kittel-SchneiderUniversity Hospital of Würzburg.ORCID 0000-0003-3057-6150
Ewa Ferensztajn-RochowiakLandesklinikum Neunkirchen.
Barbara KönigLandesklinikum Neunkirchen.
Ichiro KusumiHokkaido University Graduate School of Medicine.ORCID 0000-0002-8747-5070
Gonzalo LajeGothenburg University.
Mikael LandénGothenburg University.ORCID 0000-0002-4496-6451
Catharina LavebrattKarolinska Institutet.ORCID 0000-0003-4987-2718
Marion LeboyerVA San Diego Healthcare System.ORCID 0000-0001-5473-3697
Susan G LeckbandVA San Diego Healthcare System.
Alfonso TortorellaUniversity of Naples SUN, University of Perugia.ORCID 0000-0002-8095-2305
Mirko ManchiaVA San Diego Healthcare System.
Lina MartinssonVA San Diego Healthcare System.
Michael McCarthyVA San Diego Healthcare System.ORCID 0000-0001-6219-4945
Susan L McElroyLindner Center of Hope / University of Cincinnati.
Francesc ColomInstitut Hospital del Mar d'Investigacions Mèdiques.
Marina MitjansMax Planck Institute of Experimental Medicine, Göttingen, Germany.
Francis MondimoreJohns Hopkins University.
Palmiero MonteleoneUniversity of Salerno.
Caroline NievergeltSchool of Medicine & University Hospital Bonn.
Markus NöthenSchool of Medicine & University Hospital Bonn.ORCID 0000-0002-8770-2464
Tomas NovakDalhousie University.ORCID 0000-0001-9156-9654
Claire O'DonovanDalhousie University.
Norio OzakiUniversity of Salerno.
Andrea PfennigUniversity Hospital Carl Gustav Carus, TU Dresden.
Claudia PisanuUniversity of Cagliari.ORCID 0000-0002-9151-4319
James PotashUniversity Hospital Frankfurt, Germany.
Andreas ReifUniversity Hospital Frankfurt, Germany.ORCID 0000-0002-0992-634X
Eva ReininghausMcGill University.ORCID 0000-0001-5964-4087
Guy RouleauMcGill University.ORCID 0000-0001-8403-1418
Janusz K RybakowskiPoznan University of Medical Sciences.
Martin SchallingKarolinska Institutet.ORCID 0000-0001-5011-2922
Peter SchofieldNeuroscience Research Australia.ORCID 0000-0003-2967-9662
Barbara W SchweizerJohns Hopkins University.
Giovanni SeverinoUniversity of Cagliari.ORCID 0000-0002-6354-2662
Paul D ShillingUniversity of Salerno.
Kazutaka ShimodaUniversita degli Studi Di Cagliari.ORCID 0000-0002-9663-6243
Christian SimhandlUniversita degli Studi Di Cagliari.
Claire SlaneyUniversita degli Studi Di Cagliari.
Alessio SquassinaUniversita degli Studi Di Cagliari.ORCID 0000-0001-7415-7607
Thomas StammCharité - Universitätsmedizin Berlin, Campus Charité Mitte.
Pavla StopkovaNational Institute of Mental Health.ORCID 0000-0003-2712-3652
Mario MajUniversity of Campania "Luigi Vanvitelli", Naples.
Gustavo TureckiMcGill University.ORCID 0000-0003-4075-2736
Eduard VietaHospital Clinic of Barcelona.ORCID 0000-0002-0548-0053
Julia VeehUniversity Hospital Frankfurt.
Stephanie WittUniversity Medical Centre Mannheim.ORCID 0000-0002-1571-1468
Adam WrightUniversity of New South Wales.
Peter ZandiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine.ORCID 0000-0001-8423-2623
Philip MitchellDalhousie University.
Michael BauerDalhousie University.
Martin AldaDalhousie University.ORCID 0000-0001-9544-3944
Marcella RietschelUniversity of Mannheim.ORCID 0000-0002-5236-6149
Francis McMahonNational Institute of Mental Health Intramural Research Program; National Institutes of Health.ORCID 0000-0002-9469-305X
Thomas G SchulzeLudwig-Maximilians-University Munich.
Vincent MillischerMayo Clinic.ORCID 0000-0003-1919-9649
Scott ClarkUniversity of Adelaide.ORCID 0000-0003-1640-5611
Bernhard BauneThe University of Munster.
Universität Hamburg · DERuhr University Bochum · DELudwig-Maximilians-Universität München · DEUniversity Children's Hospital Tübingen · DEUniversity of Cagliari · ITDalhousie University · CAVA San Diego Healthcare System · USGoethe University Frankfurt · DELMU Klinikum · DEMcGill University · CANational Taiwan University · TWUniversity of California San Diego · USInserm · FRJohns Hopkins University · USMedical University of Graz · ATThe University of Adelaide · AUUniversitätsklinikum Würzburg · DEUniversitätsmedizin Göttingen · DEUniversity of Salerno · ITWinnMed · US
Funding
The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1MMapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0MCollaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9MCOLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059556 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI SCHEFTNER, WILLIAM A · 1998 to 2007
$1.6MHuman Genetics of Addiction: A Study of Common and Specific FactorsK02DA021237 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2007 to 2011
$567kIntramural NIH HHS Z01 MH002810NCI NIH HHS P01 CA089392NIDA NIH HHS K02 DA021237NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068
Abstract
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.