Evidence map›Paper›PMID 36824893›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank.

Bingxin Zhao, Yujue Li, Zirui Fan, Zhenyi Wu, Juan Shu, Xiaochen Yang, Yilin Yang, Xifeng Wang, Bingxuan Li, Xiyao Wang and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Bingxin ZhaoDepartment of Statistics and Data Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yujue LiDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Zirui FanDepartment of Statistics and Data Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhenyi WuDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Juan ShuDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Xiaochen YangDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Yilin YangDepartment of Computer and Information Science and Electrical and Systems Engineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xifeng WangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Bingxuan LiDepartment of Computer Science, Purdue University, West Lafayette, IN 47907, USA.
Xiyao WangDepartment of Computer Science, Purdue University, West Lafayette, IN 47907, USA.
Carlos CopanaDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Yue YangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jinjie LinYale School of Management, Yale University, New Haven, CT 06511, USA.
Yun LiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jason L SteinDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Joan M O'BrienScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tengfei LiDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hongtu ZhuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USPurdue University West Lafayette · USPenn Presbyterian Medical Center · USUniversity of Pennsylvania · USYale University · US

Funding

Primary Open Angle African-American Glaucoma Genetics Study RenewalR01EY023557 · NEI · UNIVERSITY OF PENNSYLVANIA · PI O'BRIEN, JOAN M · 2014 to 2025
$18.1M
Polygenic risk scores for cardiometabolic disorders: the role of blood cells immune response and evolutionary adaptationU01HG011720 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yun Li, ALEXANDER P REINER · 2021 to 2026
$5.4M
Study of Selective Cell and System Vulnerability in Alzheimer's DiseaseR56AG079291 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAN, LI, LI, YUN · 2022 to 2022
$1.3M
NEI NIH HHS R01 EY023557NHGRI NIH HHS U01 HG011720NIA NIH HHS R56 AG079291
6 · The paper itself

Abstract

As an anatomical extension of the brain, the retina of the eye is synaptically connected to the visual cortex, establishing physiological connections between the eye and the brain. Despite the unique opportunity retinal structures offer for assessing brain disorders, less is known about their relationship to brain structure and function. Here we present a systematic cross-organ genetic architecture analysis of eye-brain connections using retina and brain imaging endophenotypes. Novel phenotypic and genetic links were identified between retinal imaging biomarkers and brain structure and function measures derived from multimodal magnetic resonance imaging (MRI), many of which were involved in the visual pathways, including the primary visual cortex. In 65 genomic regions, retinal imaging biomarkers shared genetic influences with brain diseases and complex traits, 18 showing more genetic overlaps with brain MRI traits. Mendelian randomization suggests that retinal structures have bidirectional genetic causal links with neurological and neuropsychiatric disorders, such as Alzheimer's disease. Overall, cross-organ imaging genetics reveals a genetic basis for eye-brain connections, suggesting that the retinal images can elucidate genetic risk factors for brain disorders and disease-related changes in intracranial structure and function.

Indexed as

Brain disordersBrain MRIFundus photographyGWASOCTRetinal imagingTransfer LearningUK BiobankVisual pathways

Identifiers

PMID36824893
PMCPMC9949187
OpenAlexW4321185321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.