Evidence map›Paper›PMID 36824874›Full record

ArticlebioRxiv : the preprint server for biology2023

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G McDonald, Dengke K Ma

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Taruna PandeyCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, USA.
Bingying WangCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, USA.
Changnan WangCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, USA.
Jenny ZuCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, USA.
Huichao DengDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, USA.
Kang ShenDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, USA.
Goncalo Dias do ValeCenter for Human Nutrition and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, USA.
Jeffrey G McDonaldCenter for Human Nutrition and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, USA.
Dengke K MaCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, USA.
University of California, San Francisco · USHoward Hughes Medical Institute · USThe University of Texas Southwestern Medical Center · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Patterning dendritic branches with environmental and neuronal surface moleculesR01NS082208 · NINDS · STANFORD UNIVERSITY · PI KANG SHEN · 2013 to 2026
$4.1M
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dengke Ma · 2021 to 2026
$2.3M
NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440NINDS NIH HHS R01 NS082208
6 · The paper itself

Abstract

Insulin-mTOR signaling drives anabolic growth during organismal development, while its late-life dysregulation may detrimentally contribute to aging and limit lifespans. Age-related regulatory mechanisms and functional consequences of insulin-mTOR remain incompletely understood. Here we identify LPD-3 as a megaprotein that orchestrates the tempo of insulin-mTOR signaling during

Identifiers

PMID36824874
PMCPMC9949100
OpenAlexW4320913705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.