Evidence map›Paper›PMID 36824864›Full record

ArticlebioRxiv : the preprint server for biology2023

Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure.

D Liu, F Munoz, S Sanatkhani, A N Pouliopoulos, E Konofagou, J Grinband, Ferrera Vp

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

D LiuDept. of Neuroscience, Columbia University, USA.
F MunozDept. of Neuroscience, Columbia University, USA.
S SanatkhaniDept. of Neuroscience, Columbia University, USA.
A N PouliopoulosDept. of Surgical & Interventional Engineering, School of Biomedical Engineering & Imaging Science, King's College London, UK.
E KonofagouDept. of Biomedical Engineering, Columbia University, USA.
J GrinbandDept. of Radiology, Columbia University, USA.
Ferrera VpDept. of Neuroscience, Columbia University, USA.
Columbia University · USKing's College London · GB

Funding

Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimer's DiseaseR01AG038961 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2020
$5.1M
Optimization of ultrasound-facilitated blood-brain barrier openingR01EB009041 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2008 to 2017
$4.4M
Focused ultrasound for noninvasive brain stimulationR01MH112142 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FERRERA, VINCENT P, KONOFAGOU, ELISA E. · 2017 to 2021
$2.1M
NIA NIH HHS R01 AG038961NIBIB NIH HHS R01 EB009041NIMH NIH HHS R01 MH112142
6 · The paper itself

Abstract

Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and compared changes in functional connectivity in major brain networks. We found different alteration patterns between FUS neuromodulation and FUS-mediated BBB opening in several cortical areas, and we also found that applying FUS to a deep brain structure can alter functional connectivity in the default mode network and frontotemporal network.

Identifiers

PMID36824864
PMCPMC9949083
OpenAlexW4321015023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.