Evidence map›Paper›PMID 36824822›Full record

ArticlebioRxiv : the preprint server for biology2023

A hyper-quiescent chromatin state formed during aging is reversed by regeneration.

Na Yang, James R Occean, Daniël P Melters, Changyou Shi, Lin Wang, Stephanie Stransky, Maire E Doyle, Chang-Yi Cui, Michael Delannoy, Jinshui Fan and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Na YangLaboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
James R OcceanLaboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Daniël P MeltersLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH; Bethesda, MD.
Changyou ShiLaboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Lin WangLaboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Stephanie StranskyDepartment of Biochemistry, Albert Einstein School of Medicine; Bronx, NY.
Maire E DoyleLaboratory of Clinical Investigation, National Institute on Aging, NIH; Baltimore, MD.
Chang-Yi CuiLaboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Michael DelannoyJHU SOM Microscope Facility, Johns Hopkins University; Baltimore, MD.
Jinshui FanComputational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Eliza SlamaDepartment of Surgery, Ascension Saint Agnes Hospital; Baltimore, MD.
Josephine M EganLaboratory of Clinical Investigation, National Institute on Aging, NIH; Baltimore, MD.
Supriyo DeComputational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Steven C CunninghamDepartment of Surgery, Ascension Saint Agnes Hospital; Baltimore, MD.
Rafael de CaboTranslational Gerontology Branch, National Institute on Aging, NIH; Baltimore, MD.
Simone SidoliDepartment of Biochemistry, Albert Einstein School of Medicine; Bronx, NY.
Yamini DalalLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH; Bethesda, MD.
Payel SenLaboratory of Genetics and Genomics, National Institute on Aging, NIH; Baltimore, MD.
Institute on Aging · USNational Institute on Aging · USAlbert Einstein College of Medicine · USNational Institutes of Health · USSaint Agnes Hospital · USJohns Hopkins University · US

Funding

Role of histone variants in aging and cancerZIABC011206 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DALAL, YAMINI P · 2009 to 2025
$10.4M
Epigenetic mechanisms of mammalian tissue agingZIAAG000679 · NIA · NATIONAL INSTITUTE ON AGING · PI SEN, PAYEL · 2019 to 2025
$6.9M
Orbitrap Exploris 480 Basic SystemS10OD030286 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIDOLI, SIMONE · 2021 to 2021
$600k
Intramural NIH HHS ZIA AG000679Intramural NIH HHS ZIA BC011206NIH HHS S10 OD030286
6 · The paper itself

Abstract

Epigenetic alterations are a key hallmark of aging but have been limitedly explored in tissues. Here, using naturally aged murine liver as a model and extending to other quiescent tissues, we find that aging is driven by temporal chromatin alterations that promote a refractory cellular state and compromise cellular identity. Using an integrated multi-omics approach, and the first direct visualization of aged chromatin we find that globally, old cells show H3K27me3-driven broad heterochromatinization and transcription suppression. At the local level, site-specific loss of H3K27me3 over promoters of genes encoding developmental transcription factors leads to expression of otherwise non-hepatocyte markers. Interestingly, liver regeneration reverses H3K27me3 patterns and rejuvenates multiple molecular and physiological aspects of the aged liver.

Identifiers

PMID36824822
PMCPMC9949032
OpenAlexW4320893925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.