Evidence map›Paper›PMID 36824807›Full record

ArticlebioRxiv : the preprint server for biology2023

A Photoactivated Protein Degrader for Optical Control of Synaptic Function.

T Ko, C Jou, A B Grau-Perales, M Reynders, A A Fenton, D Trauner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

T KoDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street Philadelphia, PA 19104-6323, USA.
C JouDepartment of Psychology, Hunter College, 695 Park Avenue, New York, NY, 10065, USA.
A B Grau-PeralesCenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
M ReyndersDepartment of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
A A FentonCenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
D TraunerDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street Philadelphia, PA 19104-6323, USA.

Funding

Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
NIMH NIH HHS R01 MH115304
6 · The paper itself

Abstract

Hundreds of proteins determine the function of synapses, and synapses define the neuronal circuits that subserve myriad brain, cognitive, and behavioral functions. It is thus necessary to precisely manipulate specific proteins at specific sub-cellular locations and times to elucidate the roles of particular proteins and synapses in brain function. We developed PHOtochemically TArgeting Chimeras (PHOTACs) as a strategy to optically degrade specific proteins with high spatial and temporal precision. PHOTACs are small molecules that, upon wavelength-selective illumination, catalyze ubiquitylation and degradation of target proteins through endogenous proteasomes. Here we describe the design and chemical properties of a PHOTAC that targets Ca

Identifiers

PMID36824807
PMCPMC9949324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.