Evidence map›Paper›PMID 36824795›Full record

ArticlebioRxiv : the preprint server for biology2023

Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.

Kristina M Wright, Shannon Cieslewski, Amanda Chu, Michael A McDannald

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kristina M WrightBoston College, Department of Psychology & Neuroscience.
Shannon CieslewskiBoston College, Department of Psychology & Neuroscience.
Amanda ChuBoston College, Department of Psychology & Neuroscience.
Michael A McDannaldBoston College, Department of Psychology & Neuroscience.
Boston College · US

Funding

Early life stress, neuron-type function and a raphe-amygdala circuit for threat estimationR01MH117791 · NIMH · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2018 to 2025
$4.0M
NIMH NIH HHS R01 MH117791
6 · The paper itself

Abstract

Defensive responding is adaptive when it approximates current threat, but maladaptive when it exceeds current threat. Here we asked if the substantia nigra, a region consistently implicated in reward, is necessary to show appropriate levels of defensive responding in Pavlovian fear discrimination. Rats received bilateral transduction of the caudal substantia nigra with halorhodopsin or a control fluorophore, and bilateral ferrule implants. Rats then behaviorally discriminated cues predicting unique foot shock probabilities (danger,

Identifiers

PMID36824795
PMCPMC9949108
OpenAlexW4321326024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.