Evidence map›Paper›PMID 36824786›Full record

ArticlebioRxiv : the preprint server for biology2023

A pillar/perfusion plate enhances cell growth, reproducibility, throughput, and user friendliness in dynamic 3D cell culture.

Vinod Kumar Reddy Lekkala, Soo-Yeon Kang, Jiafeng Liu, Sunil Shrestha, Prabha Acharya, Pranav Joshi, Mona Zolfaghar, Minseong Lee, Paarth Jamdagneya, Sohan Pagnis and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Vinod Kumar Reddy LekkalaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Soo-Yeon KangDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Jiafeng LiuDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Sunil ShresthaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Prabha AcharyaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Pranav JoshiBioprinting Laboratories Inc., Denton, Texas.
Mona ZolfagharDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Minseong LeeDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Paarth JamdagneyaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Sohan PagnisDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Arham KundiDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Samarth KabburDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Ung Tae KimDepartment of Civil and Environmental Engineering, Cleveland State University, Cleveland, Ohio.
Yong YangDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
Moo-Yeal LeeDepartment of Biomedical Engineering, University of North Texas, Denton, Texas.
University of North Texas · USCleveland State University · US

Funding

Modeling diabetes using an integrated plate systemUH3DK119982 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE, MOO-YEAL, WELLS, JAMES M · 2020 to 2022
$5.4M
Mechanistic Study of Developmental Neurotoxicity on 3D Cultured Stem Cell MicroarraysR01ES025779 · NIEHS · CLEVELAND STATE UNIVERSITY · PI LEE, MOO-YEAL · 2015 to 2018
$1.3M
Pillar and perfusion well plate platforms for reproducible organoid culture from iPSCR44TR003491 · NCATS · BIOPRINTING LABORATORIES, INC. · PI JOSHI, PRANAV, LEE, MOO-YEAL · 2020 to 2021
$838k
NCATS NIH HHS R44 TR003491NIDDK NIH HHS UH3 DK119982NIEHS NIH HHS R01 ES025779
6 · The paper itself

Abstract

Static three-dimensional (3D) cell culture has been demonstrated in ultralow attachment well plates, hanging droplet plates, and microtiter well plates with hydrogels or magnetic nanoparticles. Although it is simple, reproducible, and relatively inexpensive, thus potentially used for high-throughput screening, statically cultured 3D cells often suffer from the necrotic core due to limited nutrient and oxygen diffusion and waste removal and have limited

Identifiers

PMID36824786
PMCPMC9949149
OpenAlexW4321350492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.