Evidence map›Paper›PMID 36824782›Full record

ArticleResearch square2023

Distinct biological activity of Lewy body α-Synuclein strain in mice.

Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin Luk, John Trojanowski, Virginia Lee

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Norihito UemuraUniversity of Pennsylvania School of Medicine.ORCID 0000-0002-6251-0810
Nicholas MarottaUniversity of Pennsylvania School of Medicine.
Jahan AraUniversity of Pennsylvania School of Medicine.
Emily MeymandUniversity of Pennsylvania School of Medicine.
Bin ZhangUniversity of Pennsylvania.
Hiroshi KamedaJuntendo University Graduate School of Medicine.
Masato KoikeJuntendo University.ORCID 0000-0002-3174-5684
Kelvin LukUniversity of Pennsylvania.ORCID 0000-0002-6591-6269
John TrojanowskiUniversity of Pennsylvania.
Virginia LeeUniversity of Pennsylvania.ORCID 0000-0003-3536-6902
Lee University · USCalifornia University of Pennsylvania · USUniversity of Pennsylvania · USJuntendo University Hospital · JP

Funding

Project IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2019 to 2023
$18.1M
NIA NIH HHS U19 AG062418
6 · The paper itself

Abstract

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated that aggregates amplified from LB-αSyn (ampLB) show distinct biological activities

Identifiers

PMID36824782
PMCPMC9949267
OpenAlexW4321082935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.