Evidence map›Paper›PMID 36824762›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Tau-Neurodegeneration

Xueying Lyu, Michael Tran Duong, Long Xie, Robin de Flores, Hayley Richardson, Gyujoon Hwang, L E M Wisse, Michael DiCalogero, Corey T McMillan, John L Robinson and 11 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Xueying Lyu
Michael Tran Duong
Long Xie
Robin de Flores
Hayley Richardson
Gyujoon Hwang
L E M Wisse
Michael DiCalogero
John L Robinson
Sharon X Xie
Murray Grossman
Edward B Lee
David J Irwin
Bradford C DickersonORCID 0000-0002-5958-3445
Christos Davatzikos
Ilya M Nasrallah
Paul A YushkevichORCID 0000-0001-8543-4016
David A Wolk
Sandhitsu R Das
Alzheimer’s Disease Neuroimaging Initiative

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Characterization of relationship between tau pathology and neurodegeneration in Alzheimer's disease using multimodal imagingR01AG072796 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Sandhitsu Das, DAVID A WOLK · 2022 to 2026
$4.0M
NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG072796
6 · The paper itself

Abstract

Variability in the relationship of tau-based neurofibrillary tangles (T) and degree of neurodegeneration (N) in Alzheimer's Disease (AD) is likely attributable to the non-specific nature of N, which is also modulated by such factors as other co-pathologies, age-related changes, and developmental differences. We studied this variability by partitioning patients within the Alzheimer's continuum into data-driven groups based on their regional T-N dissociation, which reflects the residuals after the effect of tau pathology is "removed". We found six groups displaying distinct spatial T-N

Identifiers

PMID36824762
PMCPMC9949174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.