Evidence map›Paper›PMID 36824756›Full record

ArticlebioRxiv : the preprint server for biology2023

Transmembrane protein CD69 acts as an S1PR1 agonist.

Hongwen Chen, Yu Qin, Marissa Chou, Jason G Cyster, Xiaochun Li

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hongwen ChenDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yu QinDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Marissa ChouDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jason G CysterDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Xiaochun LiDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USUniversity of California, San Francisco · US

Funding

Tissue Culture & Antibody Production CoreP01HL160487 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Helen Haskell Hobbs · 2022 to 2026
$14.9M
Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Structural and Functional investigations of Hedgehog Signaling TransductionR01GM135343 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LI, XIAOCHUN · 2019 to 2022
$1.2M
NHLBI NIH HHS P01 HL160487NIGMS NIH HHS R01 GM135343NIGMS NIH HHS T32 GM141323
6 · The paper itself

Abstract

The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector activity

Identifiers

PMID36824756
PMCPMC9949048
OpenAlexW4320914179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.