Evidence map›Paper›PMID 36824753›Full record

ArticlebioRxiv : the preprint server for biology2023

Massive Multiplexing of Spatially Resolved Single Neuron Projections with Axonal BARseq.

Li Yuan, Xiaoyin Chen, Huiqing Zhan, Henry L Gilbert, Anthony M Zador

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Li YuanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Xiaoyin ChenAllen Institute for Brain Science, Seattle, WA, USA.
Huiqing ZhanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Henry L GilbertCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Anthony M ZadorCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Funding

State-dependent Decision-making in Brainwide Neural CircuitsU19NS123716 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ZADOR, ANTHONY M · 2021 to 2025
$18.2M
High-throughput approaches to local and long-range synaptic connectivityRF1MH123403 · NIMH · COLD SPRING HARBOR LABORATORY · PI BOYDEN, EDWARD S., ZADOR, ANTHONY M · 2020 to 2020
$3.3M
NIMH NIH HHS RF1 MH123403NINDS NIH HHS U19 NS123716
6 · The paper itself

Abstract

Neurons in the cortex are heterogenous, sending diverse axonal projections to multiple brain regions. Unraveling the logic of these projections requires single-neuron resolution. Although a growing number of techniques have enabled high-throughput reconstruction, these techniques are typically limited to dozens or at most hundreds of neurons per brain, requiring that statistical analyses combine data from different specimens. Here we present axonal BARseq, a high-throughput approach based on reading out nucleic acid barcodes using

Identifiers

PMID36824753
PMCPMC9949159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.