Evidence map›Paper›PMID 36824751›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Genetic mechanisms of 184 neuro-related proteins in human plasma.

Linda Repetto, Jiantao Chen, Zhijian Yang, Ranran Zhai, Paul R H J Timmers, Ting Li, Emma L Twait, Sebastian May-Wilson, Marisa D Muckian, Bram P Prins and 35 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors.

Linda RepettoCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Jiantao ChenState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Zhijian YangState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Ranran ZhaiState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Paul R H J TimmersCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Ting LiState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Emma L TwaitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Sebastian May-WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Marisa D MuckianCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Bram P PrinsBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Grace PngInstitute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle USA.
Åsa JohanssonDept. Immunology, Genetics and Pathology, Science for life laboratory, Uppsala University, Sweden.
Robert F HillaryCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom.
Eleanor WheelerMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Lu PanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Yazhou HeCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Sofia KlassonInstitute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Shahzad AhmadDepartment of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
James E PetersDepartment of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, United Kingdom.
Arthur GillyInstitute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Maria KaraleftheriEchinos Medical Centre, Echinos, Greece.
Emmanouil TsafantakisAnogia Medical Centre, Anogia, Greece.
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle USA.
Ulf GyllenstenDept. Immunology, Genetics and Pathology, Science for life laboratory, Uppsala University, Sweden.
Sarah E HarrisLothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Andreas GötesonInstitute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Cecilia LaggingInstitute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Mohammad Arfan IkramDepartment of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
Cornelia M van DuijnDepartment of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
Christina JernInstitute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Ian J DearyLothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom.
Stefan EnrothDept. Immunology, Genetics and Pathology, Science for life laboratory, Uppsala University, Sweden.
Alexander P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Center and Department of Epidemiology, University of Washington, Seattle USA.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.
Eleftheria ZegginiInstitute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Adam S ButterworthBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Anders MälarstigDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Pau NavarroCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Xia ShenCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

Funding

Whole Genome Sequence Analysis of Ischemic Stroke in the Women's Health InitiativeR01HL136574 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L, REINER, ALEXANDER P · 2017 to 2020
$3.1M
British Heart Foundation RG/18/13/33946Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MR/L003120/1NHLBI NIH HHS R01 HL136574
6 · The paper itself

Abstract

Understanding the genetic basis of neuro-related proteins is essential for dissecting the disease etiology of neuropsychiatric disorders and other complex traits and diseases. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-reiated proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-reiated traits as well as complex diseases such as hypertension, high cholesterol, immune-related disorders, and psychiatric disorders. Integrating with established drug information, we validated 13 combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets for diseases and comorbidities. This consortium effort provides a large-scale proteogenomic resource for biomedical research.

Identifiers

PMID36824751
PMCPMC9949195

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