Evidence map›Paper›PMID 36824733›Full record

ArticlebioRxiv : the preprint server for biology2023

Ergosterol distribution controls surface structure formation and fungal pathogenicity.

Hau Lam Choy, Elizabeth A Gaylord, Tamara L Doering

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 17 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hau Lam ChoyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Elizabeth A GaylordDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · US

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
CRYPTOCOCCAL GLYCAN SYNTHESISR01AI135012 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2022
$2.5M
MITOCHONDRIAL REGULATION IN CRYPTOCOCCUS NEOFORMANSR21AI136688 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2019
$429k
Cryptococcal factors in host cell interactionsR21AI140979 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2019
$428k
NIAID NIH HHS R01 AI135012NIAID NIH HHS R21 AI136688NIAID NIH HHS R21 AI140979NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

Ergosterol, the major sterol in fungal membranes, is critical for defining membrane fluidity and regulating cellular processes. Although ergosterol synthesis has been well defined in model yeast, little is known about sterol organization in the context of fungal pathogenesis. We identified a retrograde sterol transporter, Ysp2, in the opportunistic fungal pathogen IMPORTANCE:

Identifiers

PMID36824733
PMCPMC9949117
OpenAlexW4321178759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.