Evidence map›Paper›PMID 36824732›Full record

ArticlebioRxiv : the preprint server for biology2023

Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease.

Ozioma S Chioma, Elizabeth Mallott, Binal Shah-Gandhi, ZaDarreyal Wiggins, Madison Langford, Andrew William Lancaster, Alexander Gelbard, Hongmei Wu, Joyce E Johnson, Lisa Lancaster and 7 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Ozioma S Chioma
Elizabeth Mallott
Binal Shah-Gandhi
ZaDarreyal Wiggins
Madison Langford
Andrew William Lancaster
Alexander Gelbard
Hongmei Wu
Joyce E Johnson
Lisa Lancaster
Erin M Wilfong
Leslie J Crofford
Courtney G Montgomery
Luc Van Kaer
Seth Bordenstein
Dawn C Newcomb
Wonder Puryear Drake
Vanderbilt University · USOklahoma Medical Research Foundation · USPennsylvania State University · USWashington University in St. Louis · US

Funding

Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
NHLBI NIH HHS T32 HL087738
6 · The paper itself

Abstract

Although profibrotic cytokines such as IL-17A and TGF-β1 have been implicated in interstitial lung disease (ILD) pathogenesis, interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine expression, such as phosphorylation of STAT3, have not been defined. Here we show by chromatin immunoprecipitation sequencing (ChIP-seq) analysis of primary human CD4+ T cells that regions within the

Identifiers

PMID36824732
PMCPMC9948999
OpenAlexW4320879398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.