ReviewFrontiers in endocrinology2022
Update on the surgical management of Graves' orbitopathy.
Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Comparative effectiveness of various orbital decompression techniques in treating thyroid-associated ophthalmopathy: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Metabolic Adaptations to Morning Versus Afternoon Training: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Extended endoscopic transnasal orbital decompression for dysthyroid optic neuropathy: efficacy and prognostic factors.BMC ophthalmology · 2026Article
- Changes in multimodal MRI parameters following orbital decompression surgery for thyroid-associated ophthalmopathy and their associations with clinical outcomes.Frontiers in medicine · 2026Article
- Transcriptomic Profiling of Orbital Fat Tissue and Ocular Surface Wash in Active Thyroid Eye Disease Requiring Urgent Orbital Decompression.Investigative ophthalmology & visual science · 2025Article
- Pure Endoscopic Orbital Decompression in Graves' Orbitopathy: A Comprehensive Retrospective Analysis of Objective and Subjective Outcomes.Medical sciences (Basel, Switzerland) · 2025Article
- Biomechanical Analysis and Clinical Study of Augmented Versus Conventional Endoscopic Orbital Decompression for Dysthyroid Optic Neuropathy.Bioengineering (Basel, Switzerland) · 2025Article
- Review
- Lateral Rectus Muscle Resection for New-Onset Esotropia Following Medial Orbital Wall Decompression in Thyroid Eye Disease.Medicina (Kaunas, Lithuania) · 2025Observational
- Network pharmacology and experiments verify the effect of triptolide on extraocular muscle fibrosis.PloS one · 2025Article
- Otolaryngologist surgical preferences for orbital decompression in thyroid eye disease: A North American survey.Laryngoscope investigative otolaryngology · 2024Article
- Adverse event reporting of the IGF-1R monoclonal antibody teprotumumab: a real-world study based on the US food and drug administration adverse event reporting system.Frontiers in pharmacology · 2024Article
- Alemtuzumab induces severe orbitopathy in relapsing-remitting multiple sclerosis.Journal of neurology · 2024Observational
- Differentially expressed genes in orbital adipose/connective tissue of thyroid-associated orbitopathy.PeerJ · 2023Article
- Surgical design and efficacy for restrictive strabismus due to thyroid-associated ophthalmopathy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graves' orbitopathy (GO) is a complex autoimmune disorder of the orbit that causes the eye to appear disfigured. GO is typically associated with Graves' disease, an inflammatory autoimmune condition that is caused by thyrotropin receptor autoantibodies. Although our knowledge of the pathophysiology of GO has improved, its exact pathogenesis remains unclear. Some patients suffer from disfigurement, double vision, and even vision loss rather than hyperthyroidism. The disease severity and activity prompt different treatments, as the signs of GO are heterogeneous, so their management can be very complex. Despite medical advances, the first-line treatment for moderate-to-severe active GO is still glucocorticoids, while surgery can be critical for the treatment of chronic inactive GO. Surgery is sometimes required in the acute phase of the disease when there is an immediate risk to vision, such as in dysthyroid optic neuropathy. Most surgeries for GO are rehabilitative and subdivided into three categories: decompression, strabismus repair, and lid surgery. This review is a basic overview of the field, with up-to-date knowledge of the surgical techniques for GO. We review and summarize recent literature on the advances in surgery for GO to provide up-to-date insights on the optimal surgical treatment for GO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.