Evidence map›Paper›PMID 36824581›Full record

ArticleCase reports in neurology

Hope, Cure, and Adverse Effects in Immunotherapy: Atezolizumab-Associated Encephalitis in Metastatic Small Cell Lung Cancer - A Case Report and Literature Review.

Eiman Y Ibrahim, Weige Charlie Zhao, Haritha Mopuru, Christopher Janowiecki, David J Regelmann

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eiman Y IbrahimInternal Medicine Residency Program, Quinnipiac University Frank H. Netter MD School of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut, USA.
Weige Charlie ZhaoInternal Medicine Residency Program, Quinnipiac University Frank H. Netter MD School of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut, USA.
Haritha MopuruInternal Medicine Residency Program, Quinnipiac University Frank H. Netter MD School of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut, USA.
Christopher JanowieckiInternal Medicine Residency Program, Quinnipiac University Frank H. Netter MD School of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut, USA.
David J RegelmannInternal Medicine Residency Program, Quinnipiac University Frank H. Netter MD School of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut, USA.
St. Vincent's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapies have been revolutionary treatments in oncological disease. Such therapies include immune checkpoint inhibitors that target programmed cell death protein, ligands, and cytotoxic T-lymphocyte-associated antigen (CTLA-4). Increased use has led to recognition of immune-related adverse events. Such events are often distinct from the typical adverse events of traditional cancer therapies. Immune-related adverse events are more commonly found to affect the skin, gastrointestinal tract, and endocrine system. The incidence of these adverse events remains low for central nervous system effects. This article describes a case of atezolizumab-associated encephalitis in a patient with metastatic small cell lung cancer.

Indexed as

AtezolizumabCancerEncephalitisImmune checkpoint inhibitorsImmunotherapy

Identifiers

PMID36824581
PMCPMC9941767
OpenAlexW4296783386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.