ReviewBiomaterials and biosystems2021
Advanced non-fluoride approaches to dental enamel remineralization: The next level in enamel repair management.
Review in Biomaterials and biosystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- A 12-months randomized clinical trial comparing fluoride-based remineralising protocols on post-orthodontic initial caries lesions.Clinical oral investigations · 2025Trial
- Biomimetic Strategies for Subsurface Enamel Remineralization: Depth-Dependent Effects of Biomimetic Agents Compared with Fluoride.Biomimetics (Basel, Switzerland) · 2026Article
- Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair.Frontiers in bioengineering and biotechnology · 2026Article
- Polyphosphate-based strategies in enamel remineralization: mechanisms, evidence, and clinical potential.Frontiers in oral health · 2026Review
- Innovative dentifrices based on bioactive silica for enamel remineralization and erosion control: an in vitro study.BMC oral health · 2025Article
- Associations Between Diet, Oral Health, and General Development in Romanian School-Age Children.Nutrients · 2025Article
- Evaluation of the remineralization potential of different bioactive glass varnishes on white spot lesions: an in vitro study.BMC oral health · 2025Article
- A synergistic approach to tooth remineralization using nano-chitosan, fluoride, and pulsed magnetic field.Scientific reports · 2025Article
- Effect of Experimental Bleaching Gels With Enzymes on Composite and Enamel.International dental journal · 2025Article
- Color Change and Color Stability of White Spot Lesions Treated with Resin Infiltration, Microabrasion, or Nano-Hydroxyapatite Remineralization: An In Vitro Study.Dentistry journal · 2025Article
- Effects of Adding Tricalcium Silicate Nanoparticles to the Universal G2 Bond Adhesive as Self-Etch Mode on the Shear Bond Strength to the Orthodontic Bracket.Clinical and experimental dental research · 2024Article
- Methods used for caries detection and diagnosis in Ontario dental practices: a cross-sectional survey.BMC oral health · 2024Article
- Comparing the remineralization potential of undemineralized dentin powder versus chicken eggshell powder on artificially induced initial enamel carious lesions: an in-vitro investigation.BMC oral health · 2024Article
- Remineralizing effect of NSF on artificial enamel caries.BMC oral health · 2024Article
- Developing Bioactive Hydrogels with Peptides for Dental Application.Biomedicines · 2024Article
- Amelogenin-inspired peptide, calcium phosphate solution, fluoride and their synergistic effect on enamel biomimetic remineralization: an in vitro pH-cycling model.BMC oral health · 2024Article
- Antibiofilm Properties and Demineralization Suppression in Early Enamel Lesions Using Dental Coating Materials.Antibiotics (Basel, Switzerland) · 2024Article
- Advances in Preventive and Therapeutic Approaches for Dental Erosion: A Systematic Review.Dentistry journal · 2023Review
- Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity.Materials (Basel, Switzerland) · 2023Article
- Development of a novel, entirely herbal-based mouthwash effective against common oral bacteria and SARS-CoV-2.BMC complementary medicine and therapies · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In modern dentistry, a minimally invasive management of early caries lesions or early-stage erosive tooth wear (ETW) with synthetic remineralization systems has become indispensable. In addition to fluoride, which is still the non-plus-ultra in these early caries/ETW treatments, a number of new developments are in the test phase or have already been commercialized. Some of these systems claim that they are comparable or even superior to fluoride in terms of their ability to remineralize enamel. Besides, their use can help avoid some of the risks associated with fluoride and support treatments of patients with a high risk of caries. Two individual non-fluoride systems can be distinguished; intrinsic and extrinsic remineralization approaches. Intrinsic (protein/peptide) systems adsorb to hydroxyapatite crystals/organics located within enamel prisms and accumulate endogenous calcium and phosphate ions from saliva, which ultimately leads to the re-growth of enamel crystals. Extrinsic remineralization systems function on the basis of the external (non-saliva) supply of calcium and phosphate to the crystals to be re-grown. This article, following an introduction into enamel (re)mineralization and fluoride-assisted remineralization, discusses the requirements for non-fluoride remineralization systems, particularly their mechanisms and challenges, and summarizes the findings that underpin the most promising advances in enamel remineralization therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.