Evidence map›Paper›PMID 36824275›Full record

ArticleiScience2023

BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection.

Duy T Le, Marcus A Florez, Pawel Kus, Brandon T Tran, Bailee Kain, Yingmin Zhu, Kurt Christensen, Antrix Jain, Anna Malovannaya, Katherine Y King

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Differential Response and Recovery Dynamics of HSPC Populations FollowingInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Duy T LeGraduate Program in Immunology, Graduate School of Biomedical Sciences (GSBS), Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Marcus A FlorezDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, 1102 Bates Street Suite 1150, Houston, TX, USA.
Pawel KusDepartment of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland.
Brandon T TranDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, 1102 Bates Street Suite 1150, Houston, TX, USA.
Bailee KainDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, 1102 Bates Street Suite 1150, Houston, TX, USA.
Yingmin ZhuProtein and Antibody Production Core, Baylor College of Medicine, Houston, TX, USA.
Kurt ChristensenProtein and Antibody Production Core, Baylor College of Medicine, Houston, TX, USA.
Antrix JainMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.
Anna MalovannayaMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.
Katherine Y KingGraduate Program in Immunology, Graduate School of Biomedical Sciences (GSBS), Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Baylor College of Medicine · USSilesian University of Technology · PL

Funding

Impact of Infection and Inflammation on Primitive HematopoiesisR35HL155672 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Katherine Yudeh King · 2021 to 2026
$5.1M
Microbiota-dependent regulation of primitive hematopoiesesR01AI141716 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.3M
The Contribution ofInfection to Preleukemic Clonal HematopoiesisR01HL136333 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2017 to 2020
$1.9M
Inflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate ImmunityR01HL134880 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2017 to 2020
$1.6M
Epigenetic modification of hematopoietic stem and progenitor cells in inflammation-induced differentiationF31HL164287 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI TRAN, BRANDON T · 2022 to 2024
$143k
The mechanism of Batf2-mediated HSC differentiation during chronic infectionF31HL154661 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LE, DUY TRI · 2020 to 2022
$103k
NHLBI NIH HHS F31 HL154661NHLBI NIH HHS F31 HL164287NHLBI NIH HHS R01 HL134880NHLBI NIH HHS R01 HL136333NHLBI NIH HHS R35 HL155672NIAID NIH HHS R01 AI141716
6 · The paper itself

Abstract

Basic leucine zipper ATF-like transcription factor 2 (BATF2), an interferon-activated immune response regulator, is a key factor responsible for myeloid differentiation and depletion of HSC during chronic infection. To delineate the mechanism of BATF2 function in HSCs, we assessed

Indexed as

Biological sciencesImmunologyMolecular physiology

Identifiers

PMID36824275
PMCPMC9942003
OpenAlexW4320000459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.