ArticleFrontiers in aging neuroscience2023
Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study.
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Unraveling the link between hypertension and depression in older adults: a meta-analysis.Frontiers in public health · 2023Pooled it
- Trial
- Bridge symptoms connecting depressive, sleep, and cognitive domains in rural older adults with type 2 diabetes: a symptom network approach.BMC geriatrics · 2026Article
- Assessment of sleep in older people within comprehensive geriatric assessments: a scoping review.Age and ageing · 2026Article
- What is the role of food consumption in the relationships between sleep duration, sleep quality, and cognitive function? A study among Chinese older adults.BMC geriatrics · 2026Article
- Longitudinal associations between changes in higher-level competence and sleep status among community-dwelling older adults in Japan.Frontiers in public health · 2026Article
- Disability in Older Adults with COPD: Prevalence, Assessment, and Influencing Factors - A Scoping Review.Clinical interventions in aging · 2026Article
- Factors associated with anxiety, depression, and cognitive impairment in individuals with hypertension: a cross-sectional study based on a Chinese population.Frontiers in cardiovascular medicine · 2026Article
- The effects of aerobic exercise on sleep quality in older adults with sleep problems: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychology · 2026Review
- Correlation analysis between sleep quality and depressive symptoms among rural elderly in China: An observational study.World journal of psychiatry · 2025Article
- The relationship between cognitive function and quality of life in older hypertension patients: a parallel mediation effect of frailty and medication discrepancies.BMC geriatrics · 2025Article
- The 12 weeks of regular exercise improves sleep quality and mood states in elderly with cognitive impairment.Sleep & breathing = Schlaf & Atmung · 2025Article
- Associations between serum lipid levels and cognitive impairment in hypertensive patients: a case-control study.BMC neurology · 2025Article
- Factors associated with cognitive function outcomes among older adults in Kuwait: A cross-sectional study.BMC geriatrics · 2025Article
- Association between sleep patterns and depression in older adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2007-2014.BMC geriatrics · 2025Article
- Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Investigating the Impact of the Number of Medication Use on Depression Among Hypertensive Patients: Results from the National Health and Nutrition Examination Survey Database.Medicina (Kaunas, Lithuania) · 2024Article
- Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer's disease in elderly.Ageing research reviews · 2024Review
- Association between intensity of physical activity and cognitive function in hypertensive patients: a case-control study.Scientific reports · 2024Article
- The relationship between healthy lifestyles and cognitive function in Chinese older adults: the mediating effect of depressive symptoms.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertension, sleep disorders, and depression are highly prevalent in the elderly population and are all associated with cognitive impairment, but the role that sleep quality and depression play in the association between hypertension and cognitive impairment is unclear. The aim of this study was to investigate whether sleep quality and depression have a mediating role in the association between hypertension and cognitive impairment. Methods: A cross-sectional study was conducted to collect data from the Tongji Hospital Comprehensive Geriatric Assessment Database. Sleep quality, depression and cognitive function were measured by the Pittsburgh Sleep Quality Index (PSQI), the Geriatric Depression Scale (GDS-15) and the Mini-Mental State Examination (MMSE), respectively. Correlation analysis, regression analysis and Bootstrap analysis were used to examine correlations between key variables and mediating effects of sleep quality and depression. Adjustments for multiple comparisons were performed using Benjamini-Hochberg adjustment for multiple testing. Results: A total of 827 participants were included, hypertension was present in 68.3% of the sample. After correcting for covariates, hypertensive patients aged 65 years or older had worse cognitive function, poorer-sleep quality and higher levels of depression. Sleep quality was significantly negatively associated with depression and cognitive function, while depression was negatively associated with cognitive function. Mediation analysis revealed that hypertension can affect cognitive function in older adults through a single mediating effect of sleep quality and depression and a chain mediating effect of sleep quality and depression. Conclusion: This study found that sleep quality and depression can mediate the relationship between hypertension and cognitive function in elderly. Enhanced supervision of sleep quality and depression in elderly patients with hypertension may be beneficial in maintaining cognitive function.
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