Evidence map›Paper›PMID 36824064›Full record

ArticleClinical kidney journal2022

Association between visit-to-visit blood pressure variability and risks of dementia in CKD patients: a nationwide observational cohort study.

Sehoon Park, Semin Cho, Soojin Lee, Yaerim Kim, Sanghyun Park, Hyeok Huh, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee and 5 more

Abstract readComment
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Asian expert consensus on high-quality hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  2. Article
  3. Article
  4. Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Sehoon ParkDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4221-2453
Semin ChoDepartment of Internal Medicine, Chungang University Gwangmyeong Hospital, Gyeonggi-do, Korea.ORCID https://orcid.org/0000-0002-6060-9032
Soojin LeeDepartment of Internal Medicine, Uijeongbu Eulji University Medical Center, Gyeonggi-do, Korea.ORCID https://orcid.org/0000-0001-5633-3961
Yaerim KimDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0003-1596-1528
Sanghyun ParkDepartment of Medical Statistics, College of Medicine, Catholic University of Korea, Seoul, Korea.
Hyeok HuhDepartment of Internal Medicine, Busan Paik Hospital, Busan, Korea.
Yong Chul KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-3215-8681
Seung Seok HanDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-0137-5261
Hajeong LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-1873-1587
Jung Pyo LeeKidney Research Institute, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-4714-1260
Kwon Wook JooDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-9941-7858
Chun Soo LimKidney Research Institute, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0001-9123-6542
Yon Su KimDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3091-2388
Kyungdo HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.ORCID https://orcid.org/0000-0002-6096-1263
Dong Ki KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-5195-7852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The association between visit-to-visit blood pressure (BP) variability and dementia risk in chronic kidney disease (CKD) patients has rarely been studied. Methods: In this retrospective observational study, individuals who received three or more general health screenings were identified in the nationwide database of Korea. Those with persistent non-dialysis-dependent CKD [estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m Results: We included 103 139 CKD patients and identified 7574 (7%) dementia events, including 5911 (6%) Alzheimer's disease cases, 886 (1%) vascular dementia events and 777 (1%) cases categorized as other types of dementia. Higher systolic BP variability was significantly associated with higher risks of all-cause dementia {[Q4 versus Q1], hazard ratio [HR] 1.173 [95% confidence interval (CI) 1.102-1.249], Conclusions: Higher visit-to-visit BP variability is significantly associated with a higher risk of dementia in CKD patients.

Indexed as

blood pressurechronic kidney diseaseepidemiologyhypertension

Identifiers

PMID36824064
PMCPMC9942440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.