ArticlePlant physiology2023
PP2C.D phosphatase SAL1 positively regulates aluminum resistance via restriction of aluminum uptake in rice.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- The Transcription Factor OsWRKY64 Interacts With OsART1 to Positively Regulate Al Resistance in Rice.Plant biotechnology journal · 2026Article
- Article
- Integrating Meta-QTL mapping and RNA-seq analysis identifies candidate genes for cold tolerance at rice seedling stage.BMC plant biology · 2026Article
- Overexpression and silencing of the cottonFrontiers in plant science · 2026Article
- Oxygen supply is a prerequisite for response to aluminum in cultured cells of tobacco (Nicotiana tabacum).Plant & cell physiology · 2025Article
- The PP2CH- and PBL27-mediated phosphorylation switch of aluminium ion receptor PSKR1/ALR1 controls plant aluminum sensing ability.Nature plants · 2025Article
- Aluminum resistance in plants: A critical review focusing on STOP1.Plant communications · 2025Review
- Genome-Wide Association-Based Identification of Alleles, Genes and Haplotypes Influencing Yield in Rice (International journal of molecular sciences · 2024Article
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- Genome-wide identification and expression analysis of the PP2C gene family in Apocynum venetum and Apocynum hendersonii.BMC plant biology · 2024Article
- OsAlR3 regulates aluminum tolerance through promoting the secretion of organic acids and the expression of antioxidant genes in rice.BMC plant biology · 2024Article
- Calmodulin-like protein CML15 interacts with PP2C46/65 to regulate papaya fruit ripening via integrating calcium, ABA and ethylene signals.Plant biotechnology journal · 2024Article
- Gibberellin-Mediated Sensitivity of Rice Roots to Aluminum Stress.Plants (Basel, Switzerland) · 2024Article
- Genome-wide analysis and expression pattern of the ZoPP2C gene family in Zingiber officinale Roscoe.BMC genomics · 2024Article
- STOP1-regulatedPlant direct · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aluminum (Al) toxicity represents a primary constraint for crop production in acidic soils. Rice (Oryza sativa) is a highly Al-resistant species; however, the molecular mechanisms underlying its high Al resistance are still not fully understood. Here, we identified SAL1 (SENSITIVE TO ALUMINUM 1), which encodes a plasma membrane (PM)-localized PP2C.D phosphatase, as a crucial regulator of Al resistance using a forward genetic screen. SAL1 was found to interact with and inhibit the activity of PM H+-ATPases, and mutation of SAL1 increased PM H+-ATPase activity and Al uptake, causing hypersensitivity to internal Al toxicity. Furthermore, knockout of NRAT1 (NRAMP ALUMINUM TRANSPORTER 1) encoding an Al uptake transporter in a sal1 background rescued the Al-sensitive phenotype of sal1, revealing that coordination of Al accumulation in the cell, wall and symplasm is critical for Al resistance in rice. By contrast, we found that mutations of PP2C.D phosphatase-encoding genes in Arabidopsis (Arabidopsis thaliana) enhanced Al resistance, which was attributed to increased malate secretion. Our results reveal the importance of PP2C.D phosphatases in Al resistance and the different strategies used by rice and Arabidopsis to defend against Al toxicity.
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