Evidence map›Paper›PMID 36823634›Full record

ArticleNutrition journal2023

A Mediterranean diet is associated with improved total antioxidant content of human breast milk and infant urine.

Samira Karbasi, Malihe Mohamadian, Mohsen Naseri, Zahra Khorasanchi, Asghar Zarban, Afsane Bahrami, Gordon A Ferns

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrition journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07457515 (Analysis of the Transmission of Overweight/Obesity in the Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07457515 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Analysis of the Transmission of Overweight/Obesity in the Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet

TypeobservationalSponsorWarsaw University of Life SciencesRan2026 to 2029Enrolled165ConditionsBody Weight, Obesity & Overweight, Human Milk/Breastfeeding, Body Composition
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Identifying Factors Associated With Breastfeeding Length Among Filipino Migrant Women in South Korea.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  9. Maternal Mediterranean Diet During Lactation and Infant Growth.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024
    Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Samira KarbasiDepartment of Molecular Medicine, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Malihe MohamadianCellular and Molecular Research Center, Department of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Mohsen NaseriCellular and Molecular Research Center, Department of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Zahra KhorasanchiDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Asghar ZarbanCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. azarban@bums.ac.ir.
Afsane BahramiClinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. BahramiAF@mums.ac.ir.
Gordon A FernsDivision of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, BN1 9PH, Sussex, UK.
Birjand University of Medical Sciences · IRBrighton and Sussex Medical School · GBImam Reza Hospital · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe composition of breast milk (BM) is dynamic and can be influenced by maternal variables that include the diet and nutritional status. This study examined the association between maternal adherence to a Mediterranean diet (MedDiet) and total antioxidant content of BM and infant urine.

methodsWe collected 350 BM samples from mothers and urine samples from their infants. The dietary intakes of the mothers were recorded using a validated 65 items-food frequency questionnaire (FFQ). The total antioxidant status of the samples was assessed using the ferric reducing/antioxidant power (FRAP), the 1, 1-diphenyl-2-picrylhydrazyl (DPPH), thiobarbituric acid reactive substances (TBARS), and thiol quantification assays. Milk protein, calcium, and triglyceride (TG) were also determined using standard biochemical kits.

resultsSubjects with the highest MedDiet scores were among the women in the highest tertile (T3) for consumption of dietary fiber, fruits, vegetables, nuts, legumes, and seeds, low-fat dairy, whole grains, and the lowest consumption of red meat, sweetened beverages, and sodium, compared to women in the first tertile (T1) with the lowest MedDiet scores. After adjustment for potential confounders, the individuals in the highest tertile for MedDiet score had a significantly higher level of milk DPPH, and infant urinary DPPH than the lowest tertile and had a significantly higher level of milk protein, FRAP and infant urinary FRAP compared to the T2 (P < 0.05). In addition, the mothers in the T3 for the MedDiet pattern had a significantly lower level of milk TG compared to those within the T1 (P < 0.05).

conclusionOur findings show that a high maternal adherence to a MedDiet can affect BM composition and their infants' urine.

Indexed as

AntioxidantsDiet, MediterraneanFemaleHumansInfantMilk, HumanMilk ProteinsNutritional StatusVegetablesAntioxidantsMilk ProteinsAntioxidant contentBreast milk macronutrientsInfant urineMediterranean dietMothers

Identifiers

PMID36823634
PMCPMC9948319
OpenAlexW4321598244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.