Evidence map›Paper›PMID 36823551›Full record

ArticleBMC infectious diseases2023

Meningitis and spondylodiscitis due to Nocardia nova in an immunocompetent patient.

F Lestin-Bernstein, M Tietke, S Schmiedel, M Dreimann, O Heese

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Frontiers in medicine · 2025
    Article
  2. Chronic meningoencephalomyelitis caused byFrontiers in medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

F Lestin-BernsteinClinical Hygiene and Infectiology, Helios Clinics of Schwerin - University Campus of Medical School Hamburg (MSH - University of Applied Sciences and Medical University), Wismarsche Str. 393-397, 19049, Schwerin, Germany. Franka.lestin-bernstein@helios-gesundheit.de.ORCID http://orcid.org/0000-0002-7416-1451
M TietkeRadiology and Neuroradiology, Helios Clinics of Schwerin - University Campus of Medical School Hamburg (MSH - University of Applied Sciences and Medical University), Schwerin, Germany.
S SchmiedelInfectiology and Tropical Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
M DreimannTrauma Surgery and Orthopaedics, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
O HeeseNeurosurgery and Spinal Surgery, Helios Clinics of Schwerin - University Campus of Medical School Hamburg (MSH - University of Applied Sciences and Medical University), Schwerin, Germany.
MSH Medical School Hamburg – University of Applied Sciences and Medical University · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisseminated nocardiosis is a very rare disease. By now only few cases of meningitis and spondylodiscitis have been reported. To our knowledge, this is the first case of meningitis caused by Nocardia nova. CASE PRESENTATION: We report on a case of bacteraemia, meningitis and spondylodiscitis caused by N. nova in an immunocompetent patient. We describe the long, difficult path to diagnosis, which took two months, including all diagnostic pitfalls. After nocardiosis was diagnosed, intravenous antibiotic therapy with ceftriaxone, later switched to imipenem/cilastatin and amikacin, led to rapid clinical improvement. Intravenous therapy was followed by oral consolidation with co-trimoxazole for 9 months without any relapse within 4 years.

conclusionsEstablishing a diagnosis of nocardiosis is a precondition for successful antibiotic therapy. This requires close communication between clinicians and laboratory staff about the suspicion of nocardiosis, than leading to prolonged cultures and specific laboratory methods, e.g. identification by 16S rDNA PCR.

Indexed as

DiscitisMeningitisNocardiaNocardia InfectionsAnti-Bacterial AgentsHumansAnti-Bacterial AgentsBacteraemiaCase reportImmunocompetentMeningitisNocardia novaSpondylodiscitis

Identifiers

PMID36823551
PMCPMC9951400
OpenAlexW4321614497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.