Evidence map›Paper›PMID 36823540›Full record

ArticleJournal of nanobiotechnology2023

Enhanced mild-temperature photothermal therapy by pyroptosis-boosted ATP deprivation with biodegradable nanoformulation.

Kaiyuan Liu, Li Zhang, Hengli Lu, Yingfei Wen, Bo Bi, Guocheng Wang, Yingying Jiang, Leli Zeng, Jing Zhao

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 48 citations in OpenAlex.

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  15. CsInternational journal of nanomedicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Kaiyuan Liu *School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
Li Zhang *School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
Hengli Lu *School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
Yingfei WenScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China.
Bo BiScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China.
Guocheng WangResearch Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, 518055, Guangdong, China.
Yingying JiangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, People's Republic of China. yjiang8@shu.edu.cn.
Leli ZengScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China. zenglli6@mail.sysu.edu.cn.
Jing ZhaoScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China. zhaoj265@mail.sysu.edu.cn.
Tongji University · CNThe Seventh Affiliated Hospital of Sun Yat-sen University · CNShanghai University · CNShenzhen Institutes of Advanced Technology · CNSun Yat-sen University · CN

Funding

National Natural Science Foundation of China No. 82102217Science and Technology Commission of Shanghai Municipality No. 21YF1413100Science and Technology Planning Project of Shenzhen Municipality JCYJ20210324122612032
6 · The paper itself

Abstract

backgroundMild-temperature photothermal therapy (mild PTT) is a safe and promising tumor therapeutic modality by alleviating the damage of healthy tissues around the tumor due to high temperature. However, its therapeutic efficiency is easily restricted by heat shock proteins (HSPs). Thus, exploitation of innovative approaches of inhibiting HSPs to enhance mild PTT efficiency is crucial for the clinical application of PTT.

resultsHerein, an innovative strategy is reported: pyroptosis-boosted mild PTT based on a Mn-gallate nanoformulation. The nanoformulation was constructed via the coordination of gallic acid (GA) and Mn

conclusionsOur in-vitro and in-vivo results demonstrate that this strategy of pyroptosis-assited PTT can achieve efficient mild PTT efficiency for osteosarcoma therapy.

Indexed as

Adenosine TriphosphateNeoplasmsPhotothermal TherapyPyroptosisCell Line, TumorHeat-Shock ProteinsHumansNanoparticlesReactive Oxygen SpeciesTemperatureAdenosine TriphosphateHeat-Shock ProteinsReactive Oxygen SpeciesATP deprivationBiodegradationMild-temperature PTTOsteosarcomaPyroptosis

Identifiers

PMID36823540
PMCPMC9948333
OpenAlexW4321599974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.