Evidence map›Paper›PMID 36823477›Full record

Trial reportEuropean journal of pediatrics2023

Comparison between Phenobarbitone and Levetiracetam as the initial anticonvulsant in preterm neonatal seizures - a pilot randomized control trial in developing country setup.

Gummalla Gyandeep, Sushree Smita Behura, Sanjay Kumar Sahu, Santosh Kumar Panda

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07284498 (Treatment of Seizures in Neonate With Hypoxic Ischemic Encephalopathy), which is not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07284498 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Treatment of Seizures in Neonate With Hypoxic Ischemic Encephalopathy

TypeinterventionalSponsorMansoura UniversityRan2026 to 2026Enrolled66ConditionsNeonatal Seizures, HIE - Hypoxic - Ischemic EncephalopathyArmsPhenobarbital, Levetiracetam
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Anti-seizure medications for neonates with seizures.The Cochrane database of systematic reviews · 2023
    Pooled it
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gummalla GyandeepDepartment of Paediatrics, Kalinga Institute of Medical Sciences, KIIT DU, 751024, Bhubaneswar, Odisha, India.
Sushree Smita BehuraDepartment of Paediatrics, Kalinga Institute of Medical Sciences, KIIT DU, 751024, Bhubaneswar, Odisha, India.ORCID http://orcid.org/0000-0002-6061-6814
Sanjay Kumar SahuDepartment of Paediatrics, Kalinga Institute of Medical Sciences, KIIT DU, 751024, Bhubaneswar, Odisha, India.ORCID http://orcid.org/0000-0003-0675-4703
Santosh Kumar PandaDepartment of Paediatrics, Kalinga Institute of Medical Sciences, KIIT DU, 751024, Bhubaneswar, Odisha, India. doc.sant@yahoo.co.in.ORCID http://orcid.org/0000-0003-0421-8747
Institute of Medical Sciences · INAll India Institute of Medical Sciences Bhubaneswar · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to compare the efficacy and safety of intravenous Levetiracetam and Phenobarbitone in the treatment of seizures in preterm neonates. It was an open-labeled, parallel randomized controlled trial conducted in a tertiary Neonatal Intensive Care Unit, India. Total 48 preterm neonates (28-36

Indexed as

EpilepsyInfant, Newborn, DiseasesAnticonvulsantsDeveloping CountriesHumansInfant, NewbornLevetiracetamPhenobarbitalPilot ProjectsSeizuresAnticonvulsantsLevetiracetamPhenobarbitalLevetiracetamNeonatal seizurePhenobarbitonePreterm

Identifiers

PMID36823477
PMCPMC9950002
OpenAlexW4321748803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.