ArticleNature methods2023
Mesoscale volumetric light-field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz.
Article in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Rapid robust high-fidelity 3D neuronal extraction from multiview calcium imaging datasets.Nature methods · 2026Article
- FACED 2.0 enables large-scale voltage and calcium imaging in vivo.Nature methods · 2026Article
- Intravital mesoscale optical imaging: challenges, techniques, and future perspectives.Biophysics reports · 2026Article
- Simultaneous thermal and large field-of-view two-photon imaging enables optimization of signal-to-noise.Neurophotonics · 2026Article
- Snapshot 3D at the speed frontier: redefining light-field microscopy for neuroimaging.PhotoniX · 2026Article
- Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.ACS photonics · 2025Review
- Real-time and universal network for volumetric imaging from microscale to macroscale at high resolution.Light, science & applications · 2025Article
- Article
- Whole-brain neural substrates of behavioral variability in the larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Review
- Volumetric voltage imaging of neuronal populations in the mouse brain by confocal light-field microscopy.Nature methods · 2024Article
- REVEALS: an open-source multi-camera GUI for rodent behavior acquisition.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- All-optical interrogation of brain-wide activity in freely swimming larval zebrafish.iScience · 2024Article
- Strength in numbers: Unleashing the potential of trans-scale scope AMATERAS for massive cell quantification.Biophysics and physicobiology · 2024Review
- Imagining the future of optical microscopy: everything, everywhere, all at once.Communications biology · 2023Review
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Authors and funding
4 authors at 1 institution in 2 countries.
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Abstract
Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields of view in the mammalian brain; however, capturing the activity of the neuronal population within such fields of view near-simultaneously and in a volumetric fashion has remained challenging as approaches for imaging scattering brain tissues typically are based on sequential acquisition. Here we present a modular, mesoscale light-field (MesoLF) imaging hardware and software solution that allows recording from thousands of neurons within volumes of ⌀ 4 × 0.2 mm, located at up to 350 µm depth in the mouse cortex, at 18 volumes per second and an effective voxel rate of ~40 megavoxels per second. Using our optical design and computational approach we show recording of ~10,000 neurons across multiple cortical areas in mice using workstation-grade computing resources.
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