Evidence map›Paper›PMID 36823332›Full record

ArticleNature methods2023

Outbreak.info genomic reports: scalable and dynamic surveillance of SARS-CoV-2 variants and mutations.

Karthik Gangavarapu, Alaa Abdel Latif, Julia L Mullen, Manar Alkuzweny, Emory Hufbauer, Ginger Tsueng, Emily Haag, Mark Zeller, Christine M Aceves, Karina Zaiets and 15 more

Abstract read
In one paragraph

Article in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 257 papers.

0numbers the graph read from it
0cells of the map it votes in
257citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

257 citing papers in PubMed.

  1. Trial
  2. Article
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  10. Article
  11. Life (Basel, Switzerland) · 2026
    Article
  12. Serial vaccination expands and refines human CD4bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

197 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Karthik GangavarapuDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. gkarthik@ucla.edu.ORCID http://orcid.org/0000-0002-5027-3440
Alaa Abdel LatifDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3713-8420
Julia L MullenDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Manar AlkuzwenyDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6069-5778
Emory HufbauerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Ginger TsuengDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9536-9115
Emily HaagDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Mark ZellerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Christine M AcevesDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Karina ZaietsDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Marco CanoDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Xinghua ZhouDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Zhongchao QianDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Rachel SattlerSkaggs Graduate School of Biological and Chemical Sciences, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6504-0191
Nathaniel L MattesonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Joshua I LevyDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Raphael T C LeeGISAID Global Data Science Initiative, Munich, Germany.ORCID http://orcid.org/0000-0001-5634-9154
Lucas FreitasGISAID Global Data Science Initiative, Munich, Germany.ORCID http://orcid.org/0000-0002-8766-0890
Sebastian Maurer-StrohGISAID Global Data Science Initiative, Munich, Germany.
GISAID Core and Curation Team
Marc A SuchardDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9818-479X
Chunlei WuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2629-6124
Andrew I SuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Kristian G AndersenDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Laura D HughesDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. lhughes@scripps.edu.ORCID http://orcid.org/0000-0003-1718-6676

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Robert F Garry · 2018 to 2026
$32.0M
Scripps Translational Science InstituteUL1TR002550 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2018 to 2022
$28.9M
CD2H - The National COVID Cohort Collaborative (N3C) IDeA CTR CollaborationU24TR002306 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CHUTE, CHRISTOPHER G, EDDY, JAMES A · 2017 to 2021
$28.9M
Scripps Clinical and Translational Science HubUM1TR004407 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI Eric Jeffrey Topol · 2023 to 2026
$24.2M
West African Emerging Infectious Disease Research Center (WA-EIDRC)U01AI151812 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD, GARRY, ROBERT F · 2020 to 2024
$13.2M
BioGPS: Extensible Web 2.0 gene portal for structured and unstructured annotationR01GM083924 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SU, ANDREW I, WU, CHUNLEI · 2008 to 2021
$5.6M
Fast and flexible Bayesian phylogenetics via modern machine learningR01AI162611 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2021 to 2025
$3.8M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
CDC HHS 75D30120C09795NCATS NIH HHS U24 TR002306NCATS NIH HHS UL1 TR002550NCATS NIH HHS UL1TR002550NCATS NIH HHS UM1 TR004407NIAID NIH HHS R01 AI153044NIAID NIH HHS R01 AI162611NIAID NIH HHS U01 AI151812NIAID NIH HHS U01AI151812NIAID NIH HHS U19 AI135995NIGMS NIH HHS R01 GM083924NIGMS NIH HHS R01GM083924
6 · The paper itself

Abstract

In response to the emergence of SARS-CoV-2 variants of concern, the global scientific community, through unprecedented effort, has sequenced and shared over 11 million genomes through GISAID, as of May 2022. This extraordinarily high sampling rate provides a unique opportunity to track the evolution of the virus in near real-time. Here, we present outbreak.info , a platform that currently tracks over 40 million combinations of Pango lineages and individual mutations, across over 7,000 locations, to provide insights for researchers, public health officials and the general public. We describe the interpretable visualizations available in our web application, the pipelines that enable the scalable ingestion of heterogeneous sources of SARS-CoV-2 variant data and the server infrastructure that enables widespread data dissemination via a high-performance API that can be accessed using an R package. We show how outbreak.info can be used for genomic surveillance and as a hypothesis-generation tool to understand the ongoing pandemic at varying geographic and temporal scales.

Indexed as

COVID-19SARS-CoV-2Disease OutbreaksGenomicsHumansMutation

Identifiers

PMID36823332
PMCPMC10399614

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.