ArticleScientific reports2023
Subspecies-level genome comparison of Lactobacillus delbrueckii.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Role of microbial interactions in the impaired cultivability of thermophilic lactic acid bacteria in natural whey starter for Parmigiano Reggiano PDO cheese production.Frontiers in microbiology · 2026Article
- Direct-fed Microbials (DFM) and Poultry Genomics: A Synergistic Approach to Sustainable Antibiotic Free Farming.Probiotics and antimicrobial proteins · 2026Review
- Complete Genome Sequence and Probiotic Characterization of Lactobacillus delbrueckii subsp. Indicus DC-3 Isolated from Traditional Indigenous Fermented Milk.Probiotics and antimicrobial proteins · 2025Article
- Observational
- A New Multilocus Sequence Typing Scheme for Lactobacillus delbrueckii subsp. bulgaricus Based on Whole-Genome Sequencing Data.Current microbiology · 2025Article
- Article
- Genomic and metabolic characterization ofApplied and environmental microbiology · 2025Article
- Genomic diversity and functional adaptation ofFrontiers in microbiology · 2025Article
- Does strain-level persistence of lactobacilli in long-term back-slopped sourdoughs inform on domestication of food-fermenting lactic acid bacteria?Applied and environmental microbiology · 2024Article
- Genomic and phenotypic imprints of microbial domestication on cheese starter cultures.Nature communications · 2024Article
- Proposal ofInternational journal of systematic and evolutionary microbiology · 2024Article
- Functional genomic analysis of the isolated potential probioticMicrobiology spectrum · 2024Article
- Multidrug resistance profile in Lactobacillus delbrueckii: a food industry species with probiotic properties.World journal of microbiology & biotechnology · 2024Review
- Deciphering the metabolism ofApplied and environmental microbiology · 2024Article
- Genomic Characterization of WildMicroorganisms · 2024Article
- Genome Analysis for Cholesterol-Lowing Action and Bacteriocin Production ofMicroorganisms · 2024Article
- Draft genome sequence and probiotic functional property analysis of Lactobacillus gasseri LM1065 for food industry applications.Scientific reports · 2023Article
- In Silico Probiogenomic Characterization ofInsects · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactobacillus delbrueckii comprises six subspecies, L. delbrueckii subsp. bulgaricus, L. delbrueckii subsp. lactis, L. delbrueckii subsp. jakobsenii, L. delbrueckii subsp. delbrueckii, L. delbrueckii subsp. sunkii, and L. delbrueckii subsp. indicus. We investigated the evolution of the six subspecies of L. delbrueckii using comparative genomics. While the defining feature of the species was the gene number increment driven by mobile elements and gene fragmentation, the repertoire of subspecies-specific gene gains and losses differed among the six subspecies. The horizontal gene transfer analyses indicated that frequent gene transfers between different subspecies had occurred when the six subspecies first diverged from the common ancestor, but recent gene exchange was confined to a subspecies implying independent evolution of the six subspecies. The subspecies bulgaricus is a homogeneous group that diverged from the other subspecies a long time ago and underwent convergent evolution. The subspecies lactis, jakobsenii, delbrueckii, and sunkii were more closely related to each other than to other subspecies. The four subspecies commonly show increasing genetic variability with increasing genome size. However, the four subspecies were distinguished by specific gene contents. The subspecies indicus forms a branch distant from the other subspecies and shows an independent evolutionary trend. These results could explain the differences in the habitat and nutritional requirements of the subspecies of L. delbrueckii.
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