SynthesisTranslational psychiatry2023
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.
Synthesis in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Structural and functional alterations in the brain gray matter among Tourette syndrome patients: a multimodal meta-analysis of fMRI and VBM studies.Journal of neurology · 2025Pooled it
- Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome.Biological psychiatry · 2024Pooled it
- Article
- Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- Decoding the triglyceride-glucose index in metabolic dysfunction-associated steatotic liver disease: integrative insights from Mendelian randomization, cross-tissue transcriptomics, and spatial multi-omics.International journal of surgery (London, England) · 2026Article
- Clinical characteristics and pharmacotherapy choices in children newly diagnosed with tic disorders in China: a retrospective cohort study.BMJ paediatrics open · 2025Article
- Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.JCPP advances · 2025Article
- Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery.The journal of headache and pain · 2025Article
- Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study.Nutrition & metabolism · 2025Article
- Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function.Clinical epigenetics · 2025Article
- Phenomenology of repetitive and restrictive behaviors and sensory phenomena in neurodevelopmental disorders: an exploratory study.BMC psychiatry · 2025Article
- Integrating transcriptomic and polygenic risk scores to enhance predictive accuracy for ischemic stroke subtypes.Human genetics · 2025Article
- Late development of OCD-like phenotypes in Dlgap1 knockout mice.Psychopharmacology · 2025Article
- Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study.BMC psychiatry · 2024Article
- Tourette syndrome research highlights from 2023.F1000Research · 2024Review
Corrections and comments
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Authors and funding
52 authors at 20 institutions in 15 countries.
Funding
Abstract
Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic risk score (PRS) of individuals in the UK Biobank data and applied a Phenome Wide Association Study (PheWAS) approach to determine the association of disease risk with a wide range of phenotypes. A total of 57 traits were found to be significantly associated with TS polygenic risk, including multiple psychosocial factors and mental health conditions such as anxiety disorder and depression. Additional associations were observed with complex non-psychiatric disorders such as Type 2 diabetes, heart palpitations, and respiratory conditions. Cross-disorder comparisons of phenotypic associations with genetic risk for other childhood-onset disorders (e.g.: attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and obsessive-compulsive disorder [OCD]) indicated an overlap in associations between TS and these disorders. ADHD and ASD had a similar direction of effect with TS while OCD had an opposite direction of effect for all traits except mental health factors. Sex-specific PheWAS analysis identified differences in the associations with TS genetic risk between males and females. Type 2 diabetes and heart palpitations were significantly associated with TS risk in males but not in females, whereas diseases of the respiratory system were associated with TS risk in females but not in males. This analysis provides further evidence of shared genetic and phenotypic architecture of different complex disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.