Evidence map›Paper›PMID 36823161›Full record

ReviewNature reviews. Disease primers2023

Fetal alcohol spectrum disorders.

Svetlana Popova, Michael E Charness, Larry Burd, Andi Crawford, H Eugene Hoyme, Raja A S Mukherjee, Edward P Riley, Elizabeth J Elliott

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 2 pooled it
155.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 2 syntheses or guidelines pooled it, 269 citations in OpenAlex.

  1. Pooled it
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  12. Assessment of GABANeuroscience letters · 2026
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 5 countries.

Svetlana PopovaInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada. lana.popova@camh.ca.ORCID 0000-0002-6308-1157
Michael E CharnessVA Boston Healthcare System, West Roxbury, MA, USA.
Larry BurdNorth Dakota Fetal Alcohol Syndrome Center, Department of Pediatrics, University of North Dakota School of Medicine and Health Sciences, Pediatric Therapy Services, Altru Health System, Grand Forks, ND, USA.
Andi CrawfordFaculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
H Eugene HoymeSanford Children's Genomic Medicine Consortium, Sanford Health, and University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA.
Raja A S MukherjeeNational UK FASD Clinic, Surrey and Borders Partnership NHS Foundation Trust, Redhill, Surrey, UK.
Edward P RileyCenter for Behavioral Teratology, San Diego State University, San Diego, CA, USA.ORCID 0000-0001-8747-891X
Elizabeth J ElliottFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Boston University · USCentre for Addiction and Mental Health · CASan Diego State University · USSanford Health · USSurrey and Borders Partnership NHS Foundation Trust · GBThe University of Sydney · AUUniversity of Auckland · NZUniversity of North Dakota · US

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
Collaboration to Establish the Prevalence of FASD in San Diego, CAU01AA019879 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAMBERS, CHRISTINA · 2010 to 2017
$9.2M
ALCOHOL AND CELL ADHESIONR37AA012974 · NIAAA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHARNESS, MICHAEL EDWARD · 2002 to 2010
$4.3M
ALCOHOL AND CELL ADHESIONR01AA012974 · NIAAA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHARNESS, MICHAEL EDWARD · 2001 to 2016
$2.4M
BLRD VA I01 BX002374NIAAA NIH HHS R01 AA012974NIAAA NIH HHS R37 AA012974NIAAA NIH HHS U01 AA019879NIAAA NIH HHS U24 AA014811
6 · The paper itself

Abstract

Alcohol readily crosses the placenta and may disrupt fetal development. Harm from prenatal alcohol exposure (PAE) is determined by the dose, pattern, timing and duration of exposure, fetal and maternal genetics, maternal nutrition, concurrent substance use, and epigenetic responses. A safe dose of alcohol use during pregnancy has not been established. PAE can cause fetal alcohol spectrum disorders (FASD), which are characterized by neurodevelopmental impairment with or without facial dysmorphology, congenital anomalies and poor growth. FASD are a leading preventable cause of birth defects and developmental disability. The prevalence of FASD in 76 countries is >1% and is high in individuals living in out-of-home care or engaged in justice and mental health systems. The social and economic effects of FASD are profound, but the diagnosis is often missed or delayed and receives little public recognition. Future research should be informed by people living with FASD and be guided by cultural context, seek consensus on diagnostic criteria and evidence-based treatments, and describe the pathophysiology and lifelong effects of FASD. Imperatives include reducing stigma, equitable access to services, improved quality of life for people with FASD and FASD prevention in future generations.

Indexed as

Fetal Alcohol Spectrum DisordersPrenatal Exposure Delayed EffectsAlcohol DrinkingEthanolFemaleHumansPregnancyQuality of LifeEthanol

Identifiers

PMID36823161
OpenAlexW4321598769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.