Evidence map›Paper›PMID 36823157›Full record

ArticleScientific data2023

Developing a standardized but extendable framework to increase the findability of infectious disease datasets.

Ginger Tsueng, Marco A Alvarado Cano, José Bento, Candice Czech, Mengjia Kang, Lars Pache, Luke V Rasmussen, Tor C Savidge, Justin Starren, Qinglong Wu and 9 more

Abstract read
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  5. Review
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  7. Review
  8. The quest to share data.Frontiers in neuroinformatics · 2025
    Article
  9. Article
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  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ginger Tsueng *Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. gtsueng@scripps.edu.ORCID 0000-0001-9536-9115
Marco A Alvarado Cano *Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
José BentoDepartment of Computer Science, Boston College, 245 Beacon St, Chestnut Hill, MA, 02467, USA.
Candice CzechDepartment of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Mengjia KangDivision of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.ORCID 0000-0002-1679-9473
Lars PacheInfectious and Inflammatory Disease Center, Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.ORCID 0000-0002-4193-1042
Luke V RasmussenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID 0000-0002-4497-8049
Tor C SavidgeTexas Children's Microbiome Center & Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Justin StarrenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Qinglong WuTexas Children's Microbiome Center & Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Jiwen XinDepartment of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Michael R YeamanDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Xinghua ZhouDepartment of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0002-9119-3906
Andrew I SuDepartment of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Chunlei WuDepartment of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0002-2629-6124
Liliana BrownOffice of Genomics and Advanced Technologies, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA.
Reed S ShabmanOffice of Genomics and Advanced Technologies, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA.
Laura D HughesDepartment of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. lhughes@scripps.edu.ORCID 0000-0003-1718-6676
NIAID Systems Biology Data Dissemination Working Group

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Robert F Garry · 2018 to 2026
$32.0M
CD2H - The National COVID Cohort Collaborative (N3C) IDeA CTR CollaborationU24TR002306 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CHUTE, CHRISTOPHER G, EICHMANN, DAVID A. · 2017 to 2021
$28.9M
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2018 to 2026
$24.7M
Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1M
Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9M
BioGPS: Extensible Web 2.0 gene portal for structured and unstructured annotationR01GM083924 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SU, ANDREW I, WU, CHUNLEI · 2008 to 2021
$5.6M
PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDRENR01NR013497 · NINR · BAYLOR COLLEGE OF MEDICINE · PI SAVIDGE, TOR C. · 2012 to 2024
$4.7M
NCATS NIH HHS U24 TR002306NCI NIH HHS 75N91019D00024NIAID NIH HHS U01 AI124290NIAID NIH HHS U01 AI124302NIAID NIH HHS U01 AI124319NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI135995NIGMS NIH HHS R01 GM083924NINR NIH HHS R01 NR013497
6 · The paper itself

Abstract

Biomedical datasets are increasing in size, stored in many repositories, and face challenges in FAIRness (findability, accessibility, interoperability, reusability). As a Consortium of infectious disease researchers from 15 Centers, we aim to adopt open science practices to promote transparency, encourage reproducibility, and accelerate research advances through data reuse. To improve FAIRness of our datasets and computational tools, we evaluated metadata standards across established biomedical data repositories. The vast majority do not adhere to a single standard, such as Schema.org, which is widely-adopted by generalist repositories. Consequently, datasets in these repositories are not findable in aggregation projects like Google Dataset Search. We alleviated this gap by creating a reusable metadata schema based on Schema.org and catalogued nearly 400 datasets and computational tools we collected. The approach is easily reusable to create schemas interoperable with community standards, but customized to a particular context. Our approach enabled data discovery, increased the reusability of datasets from a large research consortium, and accelerated research. Lastly, we discuss ongoing challenges with FAIRness beyond discoverability.

Indexed as

Communicable DiseasesDatasets as TopicHumansMetadataReproducibility of Results

Identifiers

PMID36823157
PMCPMC9950378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.