ArticleNature communications2023
Evolution of enzyme functionality in the flavin-containing monooxygenases.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Surveying aIranian journal of microbiology · 2026Article
- Investigating the versatility of cytochalasan cytochrome P450 monooxygenases using combinatorial biosynthesis reveals stereochemical restrictions.Fungal biology and biotechnology · 2026Article
- Flavin-dependent monooxygenases as versatile biocatalysts in biomanufacturing: mechanisms, engineering, and applications.Biotechnology for biofuels and bioproducts · 2026Review
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Article
- Cyanogenic millipede genome illuminates convergent evolution of cyanogenesis-related enzymes.PLoS genetics · 2025Article
- Expanding the chemical space of flavins with pentacyclic architecture.Nature communications · 2025Article
- How enzyme functions evolve: genetic, structural, and kinetic perspectives.Biophysical reviews · 2025Review
- CELF1 Promotes Post-myocardial Infarction Cardiac Remodeling Via Suppression of FMO2.Cardiovascular toxicology · 2025Article
- UnveilingFrontiers in cellular and infection microbiology · 2025Article
- Analysis of the sulfate permease family inFrontiers in plant science · 2025Article
- Ancestral Sequence Reconstruction for Designing Biocatalysts and Investigating their Functional Mechanisms.JACS Au · 2024Review
- Epithelial NSD2 maintains FMO-mediated taurine biosynthesis to prevent intestinal barrier disruption.Clinical and translational medicine · 2024Article
- Ancestral Reconstruction and the Evolution of Protein Energy Landscapes.Annual review of biophysics · 2024Review
- Evolution of Phosphorylase Activity in an Ancestral Glycosyltransferase.ACS catalysis · 2024Article
- Perspectives on Computational Enzyme Modeling: From Mechanisms to Design and Drug Development.ACS omega · 2024Review
- Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation.International journal of molecular medicine · 2023Article
- Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny.BBA advances · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the molecular mechanisms of adaptation in biology, enzyme functional diversification is indispensable. By allowing organisms to expand their catalytic repertoires and adopt fundamentally different chemistries, animals can harness or eliminate new-found substances and xenobiotics that they are exposed to in new environments. Here, we explore the flavin-containing monooxygenases (FMOs) that are essential for xenobiotic detoxification. Employing a paleobiochemistry approach in combination with enzymology techniques we disclose the set of historical substitutions responsible for the family's functional diversification in tetrapods. Remarkably, a few amino acid replacements differentiate an ancestral multi-tasking FMO into a more specialized monooxygenase by modulating the oxygenating flavin intermediate. Our findings substantiate an ongoing premise that enzymatic function hinges on a subset of residues that is not limited to the active site core.
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