Observational studyThe British journal of general practice : the journal of the Royal College of General Practitioners2023
Nitrofurantoin failure in males with an uncomplicated urinary tract infection: a primary care observational cohort study.
Observational study in The British journal of general practice : the journal of the Royal College of General Practitioners, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Epidemiology of Acute Cystitis or Afebrile Urinary Tract Infection in Adult Men: A Systematic Literature Review.Infectious diseases and therapy · 2026Review
- Mapping antibiotic treatment failure definitions and criteria in ambulatory care: a systematic literature review.JAC-antimicrobial resistance · 2026Review
- Comparative effectiveness of oral antibiotics to treat uncomplicated urinary tract infections in male outpatients.Journal of comparative effectiveness research · 2026Article
- Urinary tract infection in adults: gaps in current guidelines - opinions from an international multidisciplinary panel and relevance to clinical practice.BMC proceedings · 2025Article
- Antibiotic susceptibility patterns of bacterial uropathogens at a private tertiary hospital in Uganda: a retrospective study.BMC infectious diseases · 2025Article
- [What is confirmed in therapy of complicated urinary tract infections].Innere Medizin (Heidelberg, Germany) · 2024Review
- Rapid antibiotic susceptibility testing for urinary tract infections in secondary care in England: a cost-effectiveness analysis.BMJ open · 2024Article
- Acute cystitis in men- a nationwide study from primary care: antibiotic prescriptions, risk factors, and complications.BJGP open · 2024Article
- Phenotypic characterization of ESBL-producing urinary isolates of E. coli and Klebsiella spp. in a tertiary care children's hospital in Nepal.Tropical medicine and health · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNitrofurantoin is the first-choice antibiotic treatment for uncomplicated urinary tract infections (UTIs) in males according to the Dutch primary care UTI guideline. However, prostate involvement may be undetected and renders this treatment less suitable.
aimTo compare the nitrofurantoin failure fraction with that found with use of other antibiotics in adult males diagnosed by their GP with an uncomplicated UTI, as well as GP adherence to the Dutch primary care UTI guideline. DESIGN AND
settingRetrospective observational cohort study using routine healthcare data for males seeking care at GP practices participating in the Julius GP Network from 2014 to 2020.
methodMedical records were screened for signs and symptoms of complicated UTIs, antibiotic prescriptions, and referrals. Treatment failure was defined as prescription of a different antibiotic within 30 days after initiation of antibiotic therapy and/or acute hospital referral. The effects of age and comorbidities on failure were assessed using multivariable logistic regression.
resultsMost UTI episodes in males were uncomplicated (
conclusionNitrofurantoin failure was common in males with uncomplicated UTI and increased with age.
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