Evidence map›Paper›PMID 36823061›Full record

ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2023

Implementing antibiotic stewardship in high-prescribing English general practices: a mixed-methods study.

Sarah Tonkin-Crine, Monsey McLeod, Aleksandra J Borek, Anne Campbell, Philip Anyanwu, Céire Costelloe, Michael Moore, Benedict Hayhoe, Koen B Pouwels, Laurence Sj Roope and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Implementation of the CHIldren with acute COugh (CHICO) intervention to improve antibiotics management: a qualitative study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024
    Trial
  4. Article
  5. Article
  6. Implementing in-vitro diagnostic point-of-care tests in community health care: how can we make this work?The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Article
  7. Article
  8. Antibiotic stewardship: where next?The British journal of general practice : the journal of the Royal College of General Practitioners · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Sarah Tonkin-CrineNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford; National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford.ORCID 0000-0003-4470-1151
Monsey McLeodNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London; Centre for Medication Safety and Service Quality, Pharmacy Department, Imperial College Healthcare NHS Trust, London; and NIHR Imperial Patient Safety Translational Research Centre, Imperial College London, London.ORCID 0000-0001-5571-2417
Aleksandra J BorekNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.ORCID 0000-0001-6029-5291
Anne CampbellNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London.
Philip AnyanwuCentre for Medical Education, School of Medicine, Cardiff University, Cardiff.ORCID 0000-0003-2104-7062
Céire CostelloeInstitute of Cancer Research, London.ORCID 0000-0002-3475-7525
Michael MoorePrimary Care Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton.ORCID 0000-0002-5127-4509
Benedict HayhoePrimary Care and Public Health, Imperial College London, London.ORCID 0000-0002-2645-6191
Koen B PouwelsNuffield Department of Population Health, University of Oxford, Oxford.ORCID 0000-0001-7097-8950
Laurence Sj RoopeNuffield Department of Population Health, University of Oxford, Oxford.ORCID 0000-0001-9098-9331
Liz MorrellNuffield Department of Population Health, University of Oxford, Oxford.ORCID 0000-0001-6382-1795
Susan HopkinsUK Health Security Agency, London.ORCID 0000-0001-5179-5702
Christopher C ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.ORCID 0000-0002-0102-3453
Ann Sarah WalkerNuffield Department of Medicine, University of Oxford, Oxford; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford; and NIHR Oxford Biomedical Research Centre, Oxford.ORCID 0000-0002-0412-8509
STEP-UP study team
University of Oxford · GBImperial College London · GBCardiff University · GBInstitute of Cancer Research · CANational Institute for Health Research · GBNIHR Imperial Biomedical Research Centre · GBSouthampton City Council · GBUK Health Security Agency · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrials have identified antimicrobial stewardship (AMS) strategies that effectively reduce antibiotic use in primary care. However, many are not commonly used in England. The authors co-developed an implementation intervention to improve use of three AMS strategies: enhanced communication strategies, delayed prescriptions, and point-of-care C-reactive protein tests (POC-CRPTs).

aimTo investigate the use of the intervention in high-prescribing practices and its effect on antibiotic prescribing. DESIGN AND

settingNine high-prescribing practices had access to the intervention for 12 months from November 2019. This was primarily delivered remotely via a website with practices required to identify an 'antibiotic champion'.

methodRoutinely collected prescribing data were compared between the intervention and the control practices. Intervention use was assessed through monitoring. Surveys and interviews were conducted with professionals to capture experiences of using the intervention.

resultsThere was no evidence that the intervention affected prescribing. Engagement with intervention materials differed substantially between practices and depended on individual champions' preconceptions of strategies and the opportunity to conduct implementation tasks. Champions in five practices initiated changes to encourage use of at least one AMS strategy, mostly POC-CRPTs; one practice chose all three. POC-CRPTs was used more when allocated to one person.

conclusionClinicians need detailed information on exactly how to adopt AMS strategies. Remote, one-sided provision of AMS strategies is unlikely to change prescribing; initial clinician engagement and understanding needs to be monitored to avoid misunderstanding and suboptimal use.

Indexed as

Antimicrobial StewardshipGeneral PracticeAnti-Bacterial AgentsEnglandHumansPractice Patterns, Physicians'Surveys and QuestionnairesAnti-Bacterial Agentsantibiotic prescribingantimicrobial resistanceantimicrobial stewardshipbehaviour changecommunicationC-reactive proteindelayed prescriptionimplementationpoint-of-care testing

Identifiers

PMID36823061
PMCPMC9975978
OpenAlexW4312134957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.