ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2023
Adverse drug reactions and associated patient characteristics in older community-dwelling adults: a 6-year prospective cohort study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled it
- Reporting patterns of adverse drug withdrawal events using individual case safety reports in the FAERS and Eudravigilance databases.Exploratory research in clinical and social pharmacy · 2026Article
- Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients.Antibiotics (Basel, Switzerland) · 2026Article
- Development and Validation of an XGBoost-SHAP Model for Predicting Adverse Outcomes in Elderly Cardiovascular Patients With Polypharmacy: A Retrospective Cohort Study.Pharmacology research & perspectives · 2026Article
- Exploring the implementation and integration of structured medication reviews in primary care: a qualitative evaluation using normalisation process theory.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Clinical-pharmacological medication reviews for insurants of a German statutory health insurance fund (Kaufmännische Krankenkasse (KKH)): a 5-year retrospective analysis (2019-2023).Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Prescribing cascades potentially associated with harms before and after transition to long-term care facilities.Age and ageing · 2026Article
- Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs.Drugs & aging · 2026Article
- Associations between chronic disease profiles and self-reported adverse drug reactions in community-dwelling older adults: A cross-sectional study.Journal of Korean gerontological nursing · 2026Article
- Medication Regimen Complexity and Patient-Reported Adverse Drug Events in Korean Community Pharmacies: A Cross-Sectional Study.Pharmacy (Basel, Switzerland) · 2026Article
- Polypharmacy as a Chronic Condition: A Diagnostic Mindset for Safer and Smarter Care.Journal of clinical medicine · 2025Article
- Identifying predictors of medication-related harm in older populations: a latent class analysis approach.Age and ageing · 2025Article
- Prevalence of potentially inappropriate prescribing in community-dwelling older adults: an application of STOPP/START version 3 to The Irish Longitudinal Study on Ageing (TILDA).European geriatric medicine · 2025Article
- Reframing Polypharmacy: Empowering Medical Students to Manage Medication Burden as a Chronic Condition.Clinics and practice · 2025Article
- Prescribing Cascades Among Older Community-Dwelling Adults: Application of Prescription Sequence Symmetry Analysis to a National Database in Ireland.Annals of family medicine · 2025Article
- Clinical Pharmaceutical Care in Nursing Home Residents as a Cornerstone for Drug-Related Problems Identification.Clinical and translational science · 2025Observational
- Drug-Induced Serious Cutaneous Reactions in Hospitalized Patients: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Potential inappropriate medications and drug-drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database.Frontiers in pharmacology · 2025Article
- Article
- The patient's perspectives of safe and routine proactive deprescribing in primary care for older people living with polypharmacy: a qualitative study.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, research on adverse drug reactions (ADRs) has focused on secondary care, and there is a paucity of studies that have prospectively examined ADRs affecting older adults in general practice.
aimTo examine the cumulative incidence and severity of ADRs and associated patient characteristics in a sample of community-dwelling older adults. DESIGN AND
settingProspective cohort study of older adults (aged ≥70 years,
methodManual review of the participant's general practice electronic medical record, linked to the national dispensed prescription medicine database, and a detailed, self-reported patient postal questionnaire. The primary outcomes were ADR occurrence and severity over a 6-year period (2010-2016). Unadjusted and adjusted logistic regression models examined potential associations between patient characteristics and ADR occurrence.
resultsA total of 211 ADRs were recorded for 159 participants, resulting in a cumulative incidence of 26.9% over 6 years. The majority of ADRs detected were mild (89.1%), with the remainder classified as moderate (10.9%). Eight moderate ADRs, representing 34.8% of moderate ADRs and 3.8% of all ADRs, required an emergency hospital admission. ADRs were independently associated with female sex (adjusted odds ratio [OR] 1.83, 95% confidence interval [CI] = 1.17 to 2.85;
conclusionThis prospective cohort study of ADRs in general practice shows that over one-quarter of older adults experienced an ADR over a 6-year period. Polypharmacy is independently associated with ADR risk in general practice and older adults on ≥10 drug classes should be prioritised for regular medication review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.