Evidence map›Paper›PMID 36823038›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord.

Janet H T Song, Carolin Ruven, Payal Patel, Frances Ding, Jeffrey D Macklis, Vibhu Sahni

Open access · hybridFull text read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Corticospinal Tract Development, Evolution, and Skilled Movements.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Janet H T SongDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138.
Carolin RuvenBurke Neurological Institute, White Plains, New York 10605.
Payal PatelBurke Neurological Institute, White Plains, New York 10605.
Frances DingDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138.
Jeffrey D MacklisDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138 jeffrey_macklis@harvard.edu vis2763@med.cornell.edu.
Vibhu SahniDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138 jeffrey_macklis@harvard.edu vis2763@med.cornell.edu.ORCID 0000-0002-6215-2232
Harvard University · USCornell University · US

Funding

Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationDP1NS106665 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2017 to 2021
$5.9M
Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
Molecular Mechanisms of CTIP2 Function in Corticospinal Motor Neuron DevelopmentR01NS075672 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2012 to 2016
$1.8M
NICHD NIH HHS K12 HD093427NINDS NIH HHS DP1 NS106665NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS075672
6 · The paper itself

Abstract

Corticospinal neurons (CSN) are centrally required for skilled voluntary movement, which necessitates that they establish precise subcerebral connectivity with the brainstem and spinal cord. However, molecular controls regulating specificity of this projection targeting remain largely unknown. We previously identified that developing CSN subpopulations exhibit striking axon targeting specificity in the spinal white matter. These CSN subpopulations with segmentally distinct spinal projections are also molecularly distinct; a subset of differentially expressed genes between these distinct CSN subpopulations regulate differential axon projection targeting. Rostrolateral CSN extend axons exclusively to bulbar-cervical segments (CSN

Indexed as

AxonsSpinal CordAnimalsFemaleMaleMiceNerve Tissue ProteinsNeuritesNeuronsProtein PrecursorsCbln1 protein, mousecerebellinNerve Tissue ProteinsProtein Precursorsaxon extensioncerebellincervical-thoracic transitioncortical neuron diversityspinal segmental axon projection

Identifiers

PMID36823038
PMCPMC10027075
OpenAlexW4321607692

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read103
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.