Evidence map›Paper›PMID 36822817›Full record

ArticleOpen heart2023

Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19.

Robert Sykes, Andrew J Morrow, Alex McConnachie, Anna Kamdar, C Bagot, Hannah Bayes, Kevin G Blyth, Michael Briscoe, Heeraj Bulluck, David Carrick and 36 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04403607 (Cardiovascular and Pulmonary Imaging in SARS-CoV-2), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04403607 unknown statusnot on this map

Cardiovascular and Pulmonary Imaging in SARS-CoV-2: A Study of the Heart, Lungs and Wellbeing After COVID-19.

TypeobservationalSponsorNHS Greater Glasgow and ClydeRan2020 to 2023Enrolled180ConditionsCOVID
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 13 institutions in 1 country.

Robert SykesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0003-1010-5474
Andrew J MorrowSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Alex McConnachieRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.ORCID 0000-0002-7262-7000
Anna KamdarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
C BagotHaematology, Glasgow Royal Infirmary, Glasgow, UK.
Hannah BayesRespiratory Medicine, Glasgow Royal Infirmary, Glasgow, UK.
Kevin G BlythSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Michael BriscoeCardiology, Queen Elizabeth University Hospital, Glasgow, UK.
Heeraj BulluckCardiology, Leeds General Infirmary, Leeds, West Yorkshire, UK.
David CarrickCardiology, University Hospital Hairmyres, East Kilbride, South Lanarkshire, UK.
Colin ChurchSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
David CorcoranCardiology, Queen Elizabeth University Hospital, Glasgow, UK.
C DellesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Iain FindlayCardiology, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.
Vivienne B GibsonHaemostasis and Thrombosis, Glasgow Royal Infirmary, Glasgow, UK.
Lynsey GillespieProject Management Unit, Glasgow Clinical Research Facility, Glasgow, UK.
Douglas GrieveRespiratory Medicine, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.
Pauline Hall BarrientosMedical Physics, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UK.
Antonia HoMRC-University of Glasgow Centre for Virus Research, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
N N LangSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
David J LoweEmergency Medicine, Queen Elizabeth University Hospital, Glasgow, UK.ORCID 0000-0003-4866-2049
Vera LennieCardiology, Aberdeen Royal Infirmary, Aberdeen, Aberdeen, UK.
Peter MacFarlaneSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Kaithlin J MayneSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Patrick MarkSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0003-3387-2123
Alasdair McIntoshRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Ross McGeochCardiology, University Hospital Hairmyres, East Kilbride, South Lanarkshire, UK.
Christopher McGinleyCardiology, Queen Elizabeth University Hospital, Glasgow, UK.
Connor MckeeCardiology, Queen Elizabeth University Hospital, Glasgow, UK.
Sabrina NordinCardiology, Queen Elizabeth University Hospital, Glasgow, UK.
Alexander PayneCardiology, University Hospital Crosshouse, Kilmarnock, East Ayrshire, UK.
Alastair RankinSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Keith E RobertsonCardiology, Golden Jubilee National Hospital West of Scotland Regional Heart and Lung Centre, Glasgow, UK.
Nicola RyanCardiology, Aberdeen Royal Infirmary, Aberdeen, Aberdeen, UK.
Giles H RoditiRadiology, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UK.
Naveed SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
David B StoboRadiology, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UK.
Sarah Allwood-SpiersRespiratory Medicine, Queen Elizabeth University Hospital, Glasgow, UK.
Rhian TouyzSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Gruschen VeldtmanCardiology, Golden Jubilee National Hospital West of Scotland Regional Heart and Lung Centre, Glasgow, UK.
Sarah WeedenRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Stuart WatkinsCardiology, Golden Jubilee National Hospital West of Scotland Regional Heart and Lung Centre, Glasgow, UK.
Paul WelshSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0002-7970-3643
Ryan WereskiCentre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-6485-453X
Kenneth MangionSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Colin BerrySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK colin.berry@glasgow.ac.uk.
University of Glasgow · GBQueen Elizabeth University Hospital · GBGolden Jubilee National Hospital · GBGlasgow Royal Infirmary · GBNHS Greater Glasgow and Clyde · GBAberdeen Royal Infirmary · GBHairmyres Hospital · GBRoyal Alexandra Hospital · GBJubilee Hospital · GBLeeds General Infirmary · GBMRC University of Glasgow Centre for Virus Research · GBUniversity Hospital Crosshouse · GBUniversity of Edinburgh · GB

Funding

British Heart Foundation RE/18/6/34217Medical Research Council MC_PC_19026
6 · The paper itself

Abstract

backgroundWe investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalised post-COVID-19 individuals. METHODS AND

resultsOne hundred and sixty-eight patients were evaluated 28-60 days after the last episode of hospital care. Thirty-six (21%) were healthcare workers. Compared with non-healthcare workers, healthcare workers were of similar age (51.3 (8.7) years vs 55.0 (12.4) years; p=0.09) more often women (26 (72%) vs 48 (38%); p<0.01) and had lower 10-year cardiovascular risk (%) (8.1 (7.9) vs 15.0 (11.5); p<0.01) and Coronavirus Clinical Characterisation Consortium in-hospital mortality risk (7.3 (10.2) vs 12.7 (9.8); p<0.01). Healthcare worker status associated with less acute inflammation (peak C reactive protein 48 mg/L (IQR: 14-165) vs 112 mg/L (52-181)), milder illness reflected by WHO clinical severity score distribution (p=0.04) and shorter duration of admission (4 days (IQR: 2-6) vs 6 days (3-12)).In adjusted multivariate logistic regression analysis, healthcare worker status associated with a binary classification (probable/very likely vs not present/unlikely) of adjudicated myocarditis (OR: 2.99; 95% CI (1.01 to 8.89) by 28-60 days postdischarge).After a mean (SD, range) duration of follow-up after hospital discharge of 450 (88) days (range 290, 627 days), fewer healthcare workers died or were rehospitalised (1 (3%) vs 22 (17%); p=0.038) and secondary care referrals for post-COVID-19 syndrome were common (42%) and similar to non-healthcare workers (38%; p=0.934).

conclusionHealthcare worker status was independently associated with the likelihood of adjudicated myocarditis, despite better antecedent health. Two in five healthcare workers had a secondary care referral for post-COVID-19 syndrome. TRIAL REGISTRATION NUMBER: NCT04403607.

Indexed as

COVID-19MyocarditisAdultAftercareAgedFemaleHealth PersonnelHumansMaleMiddle AgedPatient DischargePost-Acute COVID-19 SyndromeSARS-CoV-2COVID-19Magnetic Resonance ImagingMyocarditisRisk Factors

Identifiers

PMID36822817
PMCPMC9950584
OpenAlexW4321639017

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.