Evidence map›Paper›PMID 36822800›Full record

ArticleLupus science & medicine2023

Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice.

Tsvetana Petrova, Clara Figueras-Vadillo, Sambit K Nanda, Cheryl Scudamore, Philip Cohen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tsvetana PetrovaMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Clara Figueras-VadilloMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Sambit K NandaMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Cheryl ScudamoreExepathology, Devon, UK.
Philip CohenMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK p.cohen@dundee.ac.uk.ORCID 0000-0001-7632-9492
University of Dundee · GB

Funding

Medical Research Council MR/R021406/1
6 · The paper itself

Abstract

objectiveThe aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.

methodsABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet containing pacritinib. Body weight was monitored, and serum collected at the end to measure pacritinib, autoantibody and immunoglobulin levels. Splenic immune cell populations were analysed, and the kidney, liver and lungs examined for pathology.

resultsPacritinib prevented multiple facets of the lupus phenotype in ABIN1[D485N] knock-in mice, including splenomegaly, expansion of splenic germinal centre B cells, follicular T helper cells, and neutrophils, elevated serum levels of double-stranded DNA antibodies and immunoglobulins, glomerular IgA and lung inflammation.

conclusionsPacritinib may be useful for the treatment of multiorgan inflammation in patients with lupus.

Indexed as

Lupus Erythematosus, SystemicAnimalsBridged-Ring CompoundsInflammationKidneyMicePhenotypePyrimidines11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaeneBridged-Ring CompoundsPyrimidinesAutoimmune DiseasesLupus Erythematosus, SystemicLupus Nephritis

Identifiers

PMID36822800
PMCPMC9950973
OpenAlexW4321638996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.