Evidence map›Paper›PMID 36822497›Full record

ArticleOsteoarthritis and cartilage2023

Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative.

D Voinier, T Neogi, L Arbeeva, S Voinier, H Master, L M Thoma, M Brunette, J T Jakiela, D K White

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

D VoinierDepartment of Physical Therapy, University of Delaware, Newark, DE, USA. Electronic address: mathews@udel.edu.
T NeogiDepartment of Medicine, Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA. Electronic address: tneogi@bu.edu.
L ArbeevaUniversity of North Carolina at Chapel Hill, Thurston Arthritis Research Center, Chapel Hill, NC, USA. Electronic address: liubov_arbeeva@med.unc.edu.
S VoinierDepartment of Mechanical Engineering, University of Delaware, Newark, DE, USA. Electronic address: voinier@udel.edu.
H MasterVanderbilt University Medical Center, Vanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA. Electronic address: hiral.master@vumc.org.
L M ThomaUniversity of North Carolina at Chapel Hill, Division of Physical Therapy, Chapel Hill, NC, USA. Electronic address: louise_thoma@med.unc.edu.
M BrunetteEvidation Health Inc, San Mateo, CA, USA. Electronic address: meredith.brunette@gmail.com.
J T JakielaDepartment of Physical Therapy, University of Delaware, Newark, DE, USA. Electronic address: jtjakiel@udel.edu.
D K WhiteDepartment of Physical Therapy, University of Delaware, Newark, DE, USA. Electronic address: dkw@udel.edu.
University of Delaware · USUniversity of North Carolina at Chapel Hill · USBoston University · USEvidation Health (United States) · USVanderbilt University Medical Center · US

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
A Novel Physical Therapy Administered Physical Activity Intervention After TKRR21AR071079 · NIAMS · UNIVERSITY OF DELAWARE · PI WHITE, DANIEL K · 2017 to 2019
$539k
NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIAMS NIH HHS R21 AR071079NICHD NIH HHS T32 HD007490
6 · The paper itself

Abstract

objectiveThere is continued debate as to how engaging in physical activity (PA), including moderate-to-vigorous PA (MVPA), light PA (LPA), and sedentary time (SED), affects one's risk for knee osteoarthritis (OA). Traditional regression methods do not account for the codependence of these categories of PA, whereby when one category increases, the others must decrease. Thus, we used compositional data analysis (CoDA) to examine time spent in each category of PA, or PA composition, and its association with loss of knee joint space width (JSW), a common indicator of knee OA progression.

methodsWe performed a secondary analysis of data from a subset of participants in the Osteoarthritis Initiative. These participants had minute-by-minute activity data collected over 7 days at baseline; we then categorized each minute as MVPA, LPA, or SED. Our exposure, PA composition, represented min/day spent in each category. Our outcome, medial JSW loss, was the difference in medial tibiofemoral JSW from baseline to 2 years later. We employed CoDA, using an isometric log-ratio transformation, to examine the association of PA composition with medial JSW loss over 2 years, adjusting for potential confounders.

resultsWe included 969 participants (age: 64.5 years, 56% female, body mass index [BMI]: 28.8 kg/m

conclusionUsing CoDA, PA composition was not associated with medial JSW loss over 2 years.

Indexed as

Knee JointOsteoarthritis, KneeBody Mass IndexData AnalysisExerciseFemaleHumansMaleMiddle AgedCompositional data analysisOsteoarthritisPhysical activity

Identifiers

PMID36822497
PMCPMC10523474
OpenAlexW4321438952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.