Evidence map›Paper›PMID 36822451›Full record

ArticleMagnetic resonance imaging2023

Intracranial arterial flow velocity mapping in quantitative time-of-flight MR angiography using deep machine learning.

Ioannis Koktzoglou, Rong Huang

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ioannis KoktzoglouDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA; University of Chicago Pritzker School of Medicine, Chicago, IL, USA. Electronic address: ikoktzoglou@gmail.com.
Rong HuangDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
NorthShore University HealthSystem · USUniversity of Chicago · US

Funding

Rapid Real-Time MR Angiography of Suspected StrokeR01EB027475 · NIBIB · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI KOKTZOGLOU, IOANNIS · 2018 to 2021
$1.9M
NIBIB NIH HHS R01 EB027475
6 · The paper itself

Abstract

purposeTo evaluate the application of deep machine learning (DML) to 3D quantitative time-of-flight (qTOF) magnetic resonance angiography (MRA) to measure blood flow velocity within the intracranial arteries. MATERIALS AND

methodsIntracranial qTOF MRA was acquired in 15 subjects at 3 T. Blood flow velocity quantitation with qTOF MRA was done using a non-DML computer-vision procedure, and using convolutional DML neural networks. 3D phase contrast (PC) MRA was used as the comparator. Using PC velocity measures as the output target and qTOF two-echo source image data as inputs, DML neural networks were trained to predict component blood flow velocities. Total velocities and peak intracranial arterial blood flow velocities were computed from component velocities.

resultsCompared to non-DML image analysis, DML-based analysis of qTOF MRA image data improved agreement with PC for mean component velocity (intraclass correlation coefficient (ICC) = 0.966 versus 0.939), mean total velocity (ICC = 0.835 versus 0.723), and peak velocity (ICC = 0.816 versus 0.597), as well as narrowed the 95% Bland-Altman limits of agreement for mean component velocity ([-5.16, +4.31]cm/s versus [-6.86, +6.53]cm/s), mean total velocity ([-6.78,+3.59]cm/s versus [-9.39, +7.09]cm/s) and peak velocity ([-13.5,+10.2]cm/s versus [-21.3, +10.2]cm/s). Compared to non-DML analysis, DML image analysis reduced the root-mean-square deviation from PC velocity measures by 28%-36%, and shortened calculation times by 35-fold.

conclusionThe application of DML image analysis to intracranial qTOF MRA for velocity quantitation markedly shortened calculation times, substantially improved the agreement of component, total, and peak arterial blood flow velocities, and provided excellent agreement of hemodynamic measures with respect to 3D PC.

Indexed as

Magnetic Resonance AngiographyMagnetic Resonance ImagingBlood Flow VelocityCerebral ArteriesHemodynamicsHumansImaging, Three-DimensionalMachine LearningDeep learningMRAMRIQuantitativeTOF

Identifiers

PMID36822451
PMCPMC10084710
OpenAlexW4321438566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.