Evidence map›Paper›PMID 36822439›Full record

ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2023

Intracardiac Flow Analysis of the Right Ventricle in Pediatric Patients With Repaired Tetralogy of Fallot Using a Novel Color Doppler Velocity Reconstruction.

Brett Meyers, Jonathan Nyce, Jiacheng Zhang, Lowell H Frank, Elias Balaras, Pavlos P Vlachos, Yue-Hin Loke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Brett MeyersSchool of Mechanical Engineering, Purdue University, West Lafayette, Indiana.
Jonathan NyceDepartment of Cardiology, Children's National Hospital, Washington, D.C.
Jiacheng ZhangSchool of Mechanical Engineering, Purdue University, West Lafayette, Indiana.
Lowell H FrankDepartment of Cardiology, Children's National Hospital, Washington, D.C.
Elias BalarasSchool of Engineering & Applied Science, George Washington University, Washington, D.C.
Pavlos P VlachosSchool of Mechanical Engineering, Purdue University, West Lafayette, Indiana.
Yue-Hin LokeDepartment of Cardiology, Children's National Hospital, Washington, D.C.. Electronic address: yloke@childrensnational.org.
Children's National · USPurdue University West Lafayette · USGeorge Washington University · US

Funding

Patient specific 3D printed tissue engineered vascular graft for aortic reconstruction designed by artificial intelligence algorithm.R01HL143468 · NHLBI · UNIVERSITY OF CHICAGO · PI FUGE, MARK, HIBINO, NARUTOSHI · 2018 to 2021
$2.7M
Computational Modeling of Right Ventricular Intracardiac Flow in Tetralogy of FallotR21HL156045 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LOKE, YUE-HIN · 2021 to 2022
$477k
NHLBI NIH HHS R01 HL143468NHLBI NIH HHS R21 HL156045
6 · The paper itself

Abstract

backgroundRepaired tetralogy of Fallot (RTOF) patients will develop right ventricular (RV) dysfunction from chronic pulmonary regurgitation (PR). Cardiac magnetic resonance sequences such as four-dimensional flow can demonstrate altered vorticity and flow energy loss (FEL); however, they are not as available as conventional echocardiography (echo). The study determined whether a novel, vendor-independent Doppler velocity reconstruction (DoVeR) could measure RV intracardiac flow in conventional echo of RTOF patients. The primary hypothesis was that DoVeR could detect increased vorticity and diastolic FEL in RTOF patients.

methodsRepaired tetralogy of Fallot patients with echo were retrospectively paired with age-/size-matched controls. Doppler velocity reconstruction employed the stream function-vorticity equation to approximate intracardiac flow fields from color Doppler. A velocity field of the right ventricle was reconstructed from the apical 4-chamber view. Vortex strength (VS, area integral of vorticity) and FEL were derived from DoVeR. Cardiac magnetic resonance and exercise stress parameters (performed within 1 year of echo) were collected for analysis.

resultsTwenty RTOF patients and age-matched controls were included in the study. Mean regurgitant fraction was 40.5% ± 7.6%, and indexed RV end-diastolic volume was 158 ± 36 mL/m

conclusionsDoVeR can detect alterations to intracardiac flow in RTOF patients from conventional color Doppler imaging. Echo-based measures of diastolic VS and FEL correlated with ventricular function. DoVeR has the potential to provide serial evaluation of abnormal flow dynamics in RTOF patients.

Indexed as

Pulmonary Valve InsufficiencyTetralogy of FallotVentricular Dysfunction, RightChildHeart VentriclesHumansRetrospective StudiesStroke VolumeVentricular Function, LeftVentricular Function, RightCongenital heart diseaseDoppler velocity reconstructionEnergy lossTetralogy of FallotVorticity

Identifiers

PMID36822439
PMCPMC10247486
OpenAlexW4321457232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.