ArticleMicrovascular research2023
Age-related alterations in retinal capillary function.
Article in Microvascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms.Investigative ophthalmology & visual science · 2026Review
- Retinal microvasculature and macular-choroidal thickness in oral contraceptive users: an OCTA and OCT comparative study.International journal of retina and vitreous · 2025Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Regional and Layer Specific Retinal Capillary Red Blood Cell Velocimetry in Healthy Human Subjects.Translational vision science & technology · 2025Observational
- Assessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager-A Pilot Study.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine age-related alterations in the retinal capillary function (RCF, the ability to transport blood flow) in healthy subjects.
methodsA total of 148 healthy subjects (aged 18 to 83 years) were enrolled, and one eye of each subject was imaged. Retinal blood flow (RBF) was measured using a Retinal Function Imager, and retinal capillary density (RCD, expressed as fractal dimension Dbox) was measured using optical coherence tomography angiography. RCF was defined as the ratio of RBF to RCD, representing the ability to transport blood flow. The relationship between RCF and age was analyzed. In addition, the cohort was divided into four groups (G1, <35 years, G2, 35-49 years, G3, 50-64 years, and G4, ≥65 years) for further analysis.
resultsWith all data, the relation between the RCF and age had a trend of a quadratic model (G1-4: r = 0.16, P = 0.14). After 35 years (i.e., G2-4), the relation had a trend between the RCF and age fitted into a negative linear model (r = -0.23, P = 0.05). Moreover, after 50 years (i.e., G3-4), the negative linear model became stronger (r = -0.37, P = 0.03). The average RCF was 2.24 ± 0.22 μl/s/Dbox in G4, significantly lower than that in G2 (2.65 ± 0.56 μl/s/Dbox, P = 0.018) and G3 (2.64 ± 0.70 μl/s/Dbox, P = 0.034), but did not reach a significant level compared to that in G1 (2.55 + 0.51 μl/s/Dbox, P = 0.056).
conclusionsThis is the first study to determine age-related alterations in the RCF in a healthy population. Decreased RCF in the older group may represent a characteristic pattern of normal aging.
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