Evidence map›Paper›PMID 36822361›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2023

Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study.

Indra J Das, Poonam Yadav, Aaron D Andersen, Zhe Jay Chen, Long Huang, Mark P Langer, Choonik Lee, Lin Li, Richard A Popple, Roger K Rice and 3 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Uncertainties in outcome modelling in radiation oncology.Physics and imaging in radiation oncology · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 1 country.

Indra J DasDepartment of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: indra.das@nm.org.
Poonam YadavDepartment of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Aaron D AndersenDepartment of Radiation Oncology, Renown Medical Center, Reno, NV, USA.
Zhe Jay ChenDepartment of Therapeutic Radiology, Yale University, New haven, CT, USA.
Long HuangDepartment of Radiation Oncology, University of Utah, Salt Lake City, UT, USA.
Mark P LangerDepartment of Radiation Oncology, Indiana University Health, Indianapolis, IN, USA.
Choonik LeeDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Lin LiDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Richard A PoppleDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Roger K RiceDepartment of Radiation Medicine and Applied Science, University of California, San Diego, CA, USA.
Peter B SchiffDepartment of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Timothy C ZhuDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Mohamed E AbazeedDepartment of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern Memorial Hospital · USNorthwestern University · USIndiana University Health · USNew York University · USRenown Regional Medical Center · USUniversity of Alabama at Birmingham · USUniversity of California, San Diego · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · USUniversity of Utah · USYale University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
A biomarker-driven strategy to guide the use of radiotherapy in non-small cell lung cancerR37CA222294 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABAZEED, MOHAMED E. · 2018 to 2024
$2.5M
NCI NIH HHS P30 CA060553NCI NIH HHS R37 CA222294
6 · The paper itself

Abstract

background and purposeRadiation dose prescriptions are foundational for optimizing treatment efficacy and limiting treatment-related toxicity. We sought to assess the lack of standardization of SBRT dose prescriptions across institutions. MATERIALS &

methodsDosimetric data from 1298 patients from 9 academic institutions treated with IMRT and VMAT were collected. Dose parameters D

resultsDisease sites included lung (48.3 %) followed by liver (29.7 %), prostate (7.5 %), spine (6.8 %), brain (4.1 %), and pancreas (2.5 %). The PTV volume in lung varied widely with bimodality into two main groups (22.0-28.7 cm

conclusionsThe SBRT prescriptions in the literature or in treatment guidelines currently lack nuance and hence there is significant variation in dose prescriptions across academic institutions. These findings add greater importance to the identification of dose parameters associated with improved clinical outcome comparisons as we move towards more hypofractionated treatments. There is a need for standardized reporting to help institutions in adapting treatment protocols based on the outcome of clinical trials. Dosimetric parameters are subsequently needed for uniformity and thereby standardizing planning guidelines to maximize efficacy, mitigate toxicity, and reduce treatment disparities are urgently needed.

Indexed as

RadiosurgeryRadiotherapy, Intensity-ModulatedHumansMalePrescriptionsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedDose prescription and reportingDose variabilityHomogeneity indexSBRT

Identifiers

PMID36822361
PMCPMC10121952
OpenAlexW4321438518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.