Evidence map›Paper›PMID 36822206›Full record

ArticleImmunity2023

The gut microbiota promotes distal tissue regeneration via RORγ

Bola S Hanna, Gang Wang, Silvia Galván-Peña, Alexander O Mann, Ricardo N Ramirez, Andrés R Muñoz-Rojas, Kathleen Smith, Min Wan, Christophe Benoist, Diane Mathis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
25.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 110 citations in OpenAlex.

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  9. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bola S HannaDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Gang WangDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Silvia Galván-PeñaDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Alexander O MannDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Ricardo N RamirezDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Andrés R Muñoz-RojasDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Kathleen SmithInternal Medicine Research Unit, Worldwide Research, Development & Medical, Pfizer Inc., Cambridge, MA, USA.
Min WanInternal Medicine Research Unit, Worldwide Research, Development & Medical, Pfizer Inc., Cambridge, MA, USA.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: dm@hms.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USPfizer (United States) · US

Funding

Muscle Tregs in health and diseaseR01AR070334 · NIAMS · HARVARD MEDICAL SCHOOL · PI MATHIS, DIANE J · 2016 to 2025
$3.7M
NIAMS NIH HHS R01 AR070334
6 · The paper itself

Abstract

Specific microbial signals induce the differentiation of a distinct pool of RORγ

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsMiceMice, Inbred C57BLNuclear Receptor Subfamily 1, Group F, Member 3T-Lymphocytes, RegulatoryNuclear Receptor Subfamily 1, Group F, Member 3colonIL-17livermicrobiotamuscleNASHRORγstem celltissue regenerationTreg

Identifiers

PMID36822206
PMCPMC10101925
OpenAlexW4321503800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.